exRNAdisease

Entry Detail

---



General Information

Database ID: exR0358960 RNA Name: hsa-miR-382-5p RNA Type: miRNA Chromosome: chr14 Starnd: + Coordinate: Start Site(bp): 101054316 End Site(bp): 101054337 External Links: hsa-miR-382-5p

Disease Information

Disease Name: Newborn Infant Disease Category: Other Diseases MeSH ID: D007231 Type: Age Groups/Infant Alias: Infant, Newborn//Infants, Newborn//Newborn Infant//Newborn Infants//Newborns//Newborn//Neonate//Neonates

Expression Detail

GEO ID: GSE65203 Description: microRNA as a new immune-regulatory agent in breast milk Experimental Design: Disease vs Control Case Disease Type: Newborn Infant Case Disease SubType: NA Case Sample: Deliver < 28 days Control Sample: Deliver > 28 days Number of Case: 2 Number of Control: 4 Number of Samples: 6

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand APCDD1 chr18 10454635 10489949 + BCAS2 chr1 114567557 114581629 - BCL2L11 chr2 111119378 111168445 + CAMTA1 chr1 6785454 7769706 + COBLL1 chr2 164653624 164843679 - ELK1 chrX 47635521 47650604 - FOSL1 chr11 65892049 65900573 - IGF2BP3 chr7 23310209 23470491 - KMT5A chr12 123383773 123409353 + MAPRE2 chr18 34976928 35143470 + NID1 chr1 235975830 236065109 - PARM1 chr4 74933095 75050115 + PDE8A chr15 84980440 85139145 + RAB18 chr10 27504174 27542237 + SCAF11 chr12 45919131 45992120 - SH3GL1 chr19 4360370 4400547 - STEAP3 chr2 119223831 119265652 + STK40 chr1 36339624 36385896 - TAGLN chr11 117199370 117207464 + TUB chr11 8019244 8106112 + UBN2 chr7 139230356 139308236 + WDR4 chr21 42843094 42879568 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC092718.4 chr16 81030770 81031485 + AC126365.1 chr17 20788071 20789584 + FGD5-AS1 chr3 14920347 14948424 - NEAT1 chr11 65422774 65445540 + NORAD chr20 36045618 36051018 - TUG1 chr22 30969245 30979395 + Display:

Experiment Detail

GEO ID: GSE65203 Sample Source: Breast Milk Source Fraction: Supernatant Platform: GPL7731 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 548 Sample treatment protocol: NA RNA Extract protocol: Total RNA extracted using mirVana miRNA isolation kit following manufacturer's instructions. RNA library preparation protocol: 70 ng of each RNA sample was labeled with the miRNA Complete Labeling Reagent and Hybridization kit (Agilent Technologies) according to the manufacturer's instructions.

Reference

PMID: 20226005 Title: microRNA as a new immune-regulatory agent in breast milk Author: Kosaka N, Izumi H, Sekine K, Ochiya T. Journal: Silence. 2010 Mar 1;1(1):7. Description: BACKGROUND: Breast milk is a complex liquid that provides nutrition to the infant and facilitates the maturation of the infant's immune system. Recent studies indicated that microRNA (miRNA) exists in human body fluid. Because miRNAs are known to regulate various immune systems, we hypothesized that human breast milk contains miRNAs that may be important for the development of the infant's immune system.