exRNAdisease

Entry Detail

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General Information

Database ID: exR0358979 RNA Name: hsa-miR-449b-5p RNA Type: miRNA Chromosome: chr5 Starnd: - Coordinate: Start Site(bp): 55170706 End Site(bp): 55170727 External Links: hsa-miR-449b-5p

Disease Information

Disease Name: Newborn Infant Disease Category: Other Diseases MeSH ID: D007231 Type: Age Groups/Infant Alias: Infant, Newborn//Infants, Newborn//Newborn Infant//Newborn Infants//Newborns//Newborn//Neonate//Neonates

Expression Detail

GEO ID: GSE65203 Description: microRNA as a new immune-regulatory agent in breast milk Experimental Design: Disease vs Control Case Disease Type: Newborn Infant Case Disease SubType: NA Case Sample: Deliver < 28 days Control Sample: Deliver > 28 days Number of Case: 2 Number of Control: 4 Number of Samples: 6

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand MID1 chrX 10445310 10833654 - JPH1 chr8 74234700 74321540 - TAOK1 chr17 29390464 29551904 + DEDD2 chr19 42198598 42220140 - PTPRJ chr11 47980558 48170841 + GNA12 chr7 2728105 2844308 - HNRNPUL1 chr19 41262496 41307787 + ZNF623 chr8 143636013 143656418 + SUPT6H chr17 28662198 28702679 + NCOR1 chr17 16029157 16218185 - IGSF3 chr1 116574399 116667755 - ANKRD52 chr12 56237807 56258384 - ESS2 chr22 19130279 19144684 - TNRC6B chr22 40044817 40335808 + ZIC5 chr13 99962964 99971909 - JRK chr8 142657460 142681968 - GATAD2B chr1 153789030 153923360 - ATXN7L3 chr17 44191805 44200113 - AMER1 chrX 64185117 64205708 - STK38L chr12 27243968 27325959 + SH3PXD2A chr10 103594027 103855543 - CD151 chr11 832887 839831 + NPTX1 chr17 80466834 80477843 - MYCN chr2 15940550 15947007 + NDST1 chr5 150485818 150558211 + TMEM109 chr11 60914158 60923443 + ERGIC1 chr5 172834251 172952683 + RTL8B chrX 135020513 135022542 - FGFRL1 chr4 1009936 1026898 + IL2RB chr22 37125843 37175054 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001723 chr7 91924202 91948826 + hsa_circ_0001495 chr5 68470703 68471364 + hsa_circ_0000943 chr19 47421744 47440665 + hsa_circ_0000038 chr1 28800065 28802803 + hsa_circ_0001865 chr9 86292641 86293514 - hsa_circ_0001146 chr20 34241449 34246936 - hsa_circ_0001164 chr20 45891031 45923523 - lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC018521.1 chr17 47945424 47981736 + AC116913.1 chr15 66488658 66492109 - HCG18 chr6 30286690 30327382 - KCNQ1OT1 chr11 2608328 2699994 - LINC00665 chr19 36313067 36331770 - NEAT1 chr11 65422774 65445540 + SNHG7 chr9 136721366 136728184 - TERC chr3 169764520 169765060 - XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE65203 Sample Source: Breast Milk Source Fraction: Supernatant Platform: GPL7731 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 548 Sample treatment protocol: NA RNA Extract protocol: Total RNA extracted using mirVana miRNA isolation kit following manufacturer's instructions. RNA library preparation protocol: 70 ng of each RNA sample was labeled with the miRNA Complete Labeling Reagent and Hybridization kit (Agilent Technologies) according to the manufacturer's instructions.

Reference

PMID: 20226005 Title: microRNA as a new immune-regulatory agent in breast milk Author: Kosaka N, Izumi H, Sekine K, Ochiya T. Journal: Silence. 2010 Mar 1;1(1):7. Description: BACKGROUND: Breast milk is a complex liquid that provides nutrition to the infant and facilitates the maturation of the infant's immune system. Recent studies indicated that microRNA (miRNA) exists in human body fluid. Because miRNAs are known to regulate various immune systems, we hypothesized that human breast milk contains miRNAs that may be important for the development of the infant's immune system.