exRNAdisease

Entry Detail

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General Information

Database ID: exR0358984 RNA Name: hsa-miR-455-3p RNA Type: miRNA Chromosome: chr9 Starnd: + Coordinate: Start Site(bp): 114209487 End Site(bp): 114209507 External Links: hsa-miR-455-3p

Disease Information

Disease Name: Newborn Infant Disease Category: Other Diseases MeSH ID: D007231 Type: Age Groups/Infant Alias: Infant, Newborn//Infants, Newborn//Newborn Infant//Newborn Infants//Newborns//Newborn//Neonate//Neonates

Expression Detail

GEO ID: GSE65203 Description: microRNA as a new immune-regulatory agent in breast milk Experimental Design: Disease vs Control Case Disease Type: Newborn Infant Case Disease SubType: NA Case Sample: Deliver < 28 days Control Sample: Deliver > 28 days Number of Case: 2 Number of Control: 4 Number of Samples: 6

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ACKR3 chr2 236567787 236582354 + COL18A1 chr21 45405165 45513720 + DMWD chr19 45782947 45792845 - IGFBP4 chr17 40443450 40457725 + MEPCE chr7 100428790 100434118 + NFIB chr9 14081843 14398983 - PGRMC1 chrX 119236245 119244466 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001791 chr8 38879161 38880844 + hsa_circ_0000987 chr2 30748452 30756180 + hsa_circ_0001368 chr3 183361267 183390272 + hsa_circ_0000494 chr13 76134888 76143643 + hsa_circ_0000106 chr1 111690263 111703918 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC016876.2 chr17 7581964 7584086 - AC021078.1 chr5 149494314 149504670 - AC074117.1 chr2 27356246 27367622 + AC144548.1 chr12 110387463 110445548 - AL137782.1 chr13 75549773 75807120 + DICER1-AS1 chr14 95157645 95181475 + DLEU2 chr13 49956670 50125720 - MIR29B2CHG chr1 207801518 207879115 - NEAT1 chr11 65422774 65445540 + SNHG16 chr17 76557764 76565348 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE65203 Sample Source: Breast Milk Source Fraction: Supernatant Platform: GPL7731 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 548 Sample treatment protocol: NA RNA Extract protocol: Total RNA extracted using mirVana miRNA isolation kit following manufacturer's instructions. RNA library preparation protocol: 70 ng of each RNA sample was labeled with the miRNA Complete Labeling Reagent and Hybridization kit (Agilent Technologies) according to the manufacturer's instructions.

Reference

PMID: 20226005 Title: microRNA as a new immune-regulatory agent in breast milk Author: Kosaka N, Izumi H, Sekine K, Ochiya T. Journal: Silence. 2010 Mar 1;1(1):7. Description: BACKGROUND: Breast milk is a complex liquid that provides nutrition to the infant and facilitates the maturation of the infant's immune system. Recent studies indicated that microRNA (miRNA) exists in human body fluid. Because miRNAs are known to regulate various immune systems, we hypothesized that human breast milk contains miRNAs that may be important for the development of the infant's immune system.