exRNAdisease

Entry Detail

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General Information

Database ID: exR0358998 RNA Name: hsa-miR-493-3p RNA Type: miRNA Chromosome: chr14 Starnd: + Coordinate: Start Site(bp): 100869116 End Site(bp): 100869137 External Links: hsa-miR-493-3p

Disease Information

Disease Name: Newborn Infant Disease Category: Other Diseases MeSH ID: D007231 Type: Age Groups/Infant Alias: Infant, Newborn//Infants, Newborn//Newborn Infant//Newborn Infants//Newborns//Newborn//Neonate//Neonates

Expression Detail

GEO ID: GSE65203 Description: microRNA as a new immune-regulatory agent in breast milk Experimental Design: Disease vs Control Case Disease Type: Newborn Infant Case Disease SubType: NA Case Sample: Deliver < 28 days Control Sample: Deliver > 28 days Number of Case: 2 Number of Control: 4 Number of Samples: 6

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ANKS1A chr6 34889255 35091406 + ASF1B chr19 14119512 14136613 - BACH2 chr6 89926528 90296908 - BRPF3 chr6 36196744 36232790 + C17orf49 chr17 7014495 7017525 + DYNLRB1 chr20 34516409 34540958 + EPG5 chr18 45847609 45967329 - HIF1AN chr10 100529072 100559998 + MEX3A chr1 156072013 156082465 - MFN2 chr1 11980181 12013514 + MMGT1 chrX 135962070 135974063 - MTUS1 chr8 17643795 17800917 - NPTX1 chr17 80466834 80477843 - PRKAR2A chr3 48744597 48847874 - PXN chr12 120210439 120265771 - RNASEK-C17orf49 chr17 7012635 7017520 + XPO6 chr16 28097979 28211920 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001146 chr20 34241449 34246936 - lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC016831.1 chr7 130876809 130913310 - AC016876.2 chr17 7581964 7584086 - AC022167.2 chr16 8848105 8860456 + AC144548.1 chr12 110387463 110445548 - AL359924.1 chr1 237862175 237928321 + MIR200CHG chr12 6963246 6964447 + TUG1 chr22 30969245 30979395 + Display:

Experiment Detail

GEO ID: GSE65203 Sample Source: Breast Milk Source Fraction: Supernatant Platform: GPL7731 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 548 Sample treatment protocol: NA RNA Extract protocol: Total RNA extracted using mirVana miRNA isolation kit following manufacturer's instructions. RNA library preparation protocol: 70 ng of each RNA sample was labeled with the miRNA Complete Labeling Reagent and Hybridization kit (Agilent Technologies) according to the manufacturer's instructions.

Reference

PMID: 20226005 Title: microRNA as a new immune-regulatory agent in breast milk Author: Kosaka N, Izumi H, Sekine K, Ochiya T. Journal: Silence. 2010 Mar 1;1(1):7. Description: BACKGROUND: Breast milk is a complex liquid that provides nutrition to the infant and facilitates the maturation of the infant's immune system. Recent studies indicated that microRNA (miRNA) exists in human body fluid. Because miRNAs are known to regulate various immune systems, we hypothesized that human breast milk contains miRNAs that may be important for the development of the infant's immune system.