exRNAdisease

Entry Detail

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General Information

Database ID: exR0359051 RNA Name: hsa-miR-524-5p RNA Type: miRNA Chromosome: chr19 Starnd: + Coordinate: Start Site(bp): 53711017 End Site(bp): 53711038 External Links: hsa-miR-524-5p

Disease Information

Disease Name: Newborn Infant Disease Category: Other Diseases MeSH ID: D007231 Type: Age Groups/Infant Alias: Infant, Newborn//Infants, Newborn//Newborn Infant//Newborn Infants//Newborns//Newborn//Neonate//Neonates

Expression Detail

GEO ID: GSE65203 Description: microRNA as a new immune-regulatory agent in breast milk Experimental Design: Disease vs Control Case Disease Type: Newborn Infant Case Disease SubType: NA Case Sample: Deliver < 28 days Control Sample: Deliver > 28 days Number of Case: 2 Number of Control: 4 Number of Samples: 6

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand KLHL28 chr14 44924319 45042322 - NEDD4 chr15 55826922 55993746 - NR4A2 chr2 156324437 156342348 - PKN2 chr1 88684222 88836255 + SIK2 chr11 111602449 111730855 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000095 chr1 95609446 95616975 + hsa_circ_0000284 chr11 33307958 33309057 + hsa_circ_0001146 chr20 34241449 34246936 - hsa_circ_0000799 chr17 65941524 65972074 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC008738.7 chr19 33207129 33207639 + AC009022.1 chr16 69976297 70065948 - AC021078.1 chr5 149494314 149504670 - AC024940.6 chr12 31280422 31280895 - AC068768.1 chr12 123262060 123262402 + AC125257.1 chr17 41848518 41851447 - AC239868.1 chr1 149861271 149862504 + AL031595.3 chr22 44139365 44153626 + AL137129.1 chr14 61734138 61776260 + FGD5-AS1 chr3 14920347 14948424 - GAS5 chr1 173858559 173868882 - MCM3AP-AS1 chr21 46229196 46259390 + MIR29B2CHG chr1 207801518 207879115 - NEAT1 chr11 65422774 65445540 + NORAD chr20 36045618 36051018 - PITPNA-AS1 chr17 1516931 1518096 + SCARNA9 chr11 93721513 93721865 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE65203 Sample Source: Breast Milk Source Fraction: Supernatant Platform: GPL7731 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 548 Sample treatment protocol: NA RNA Extract protocol: Total RNA extracted using mirVana miRNA isolation kit following manufacturer's instructions. RNA library preparation protocol: 70 ng of each RNA sample was labeled with the miRNA Complete Labeling Reagent and Hybridization kit (Agilent Technologies) according to the manufacturer's instructions.

Reference

PMID: 20226005 Title: microRNA as a new immune-regulatory agent in breast milk Author: Kosaka N, Izumi H, Sekine K, Ochiya T. Journal: Silence. 2010 Mar 1;1(1):7. Description: BACKGROUND: Breast milk is a complex liquid that provides nutrition to the infant and facilitates the maturation of the infant's immune system. Recent studies indicated that microRNA (miRNA) exists in human body fluid. Because miRNAs are known to regulate various immune systems, we hypothesized that human breast milk contains miRNAs that may be important for the development of the infant's immune system.