exRNAdisease

Entry Detail

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General Information

Database ID: exR0359106 RNA Name: hsa-miR-625-5p RNA Type: miRNA Chromosome: chr14 Starnd: + Coordinate: Start Site(bp): 65471116 End Site(bp): 65471136 External Links: hsa-miR-625-5p

Disease Information

Disease Name: Newborn Infant Disease Category: Other Diseases MeSH ID: D007231 Type: Age Groups/Infant Alias: Infant, Newborn//Infants, Newborn//Newborn Infant//Newborn Infants//Newborns//Newborn//Neonate//Neonates

Expression Detail

GEO ID: GSE65203 Description: microRNA as a new immune-regulatory agent in breast milk Experimental Design: Disease vs Control Case Disease Type: Newborn Infant Case Disease SubType: NA Case Sample: Deliver < 28 days Control Sample: Deliver > 28 days Number of Case: 2 Number of Control: 4 Number of Samples: 6

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand PPP2R1A chr19 52190048 52229518 + SF3B3 chr16 70523791 70577670 + LRFN1 chr19 39306568 39315336 - SLC6A6 chr3 14402576 14489349 + VPS37B chr12 122865330 122896127 - SMARCC2 chr12 56162359 56189567 - WIZ chr19 15419978 15449956 - SLC7A5 chr16 87830023 87869507 - MED22 chr9 133338312 133348131 - PPARD chr6 35342558 35428191 + FAM102A chr9 127940582 127980989 - ABL2 chr1 179099330 179229684 - PPP6C chr9 125146573 125189939 - ABCF2 chr7 151207837 151227166 - ABHD14A-ACY1 chr3 51974706 51989183 + BCL9L chr11 118893875 118925608 - JUN chr1 58780791 58784047 - NUMB chr14 73275107 73458617 - SDF2 chr17 28648346 28662189 - SREBF2 chr22 41833079 41907307 + COL6A2 chr21 46098112 46132848 + ACY1 chr3 51983340 51989197 + E2F1 chr20 33675477 33686385 - PRDX2 chr19 12796820 12801800 - MSI1 chr12 120341330 120369164 - COPS7B chr2 231781671 231809254 + CPSF7 chr11 61402641 61430031 - SCAMP4 chr19 1905372 1926013 + ITGA5 chr12 54395261 54419266 - RNF44 chr5 176526712 176538025 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001434 chr4 106345352 106377902 - hsa_circ_0001409 chr4 48835417 48859382 + hsa_circ_0001358 chr3 169694733 169706147 + hsa_circ_0001146 chr20 34241449 34246936 - lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC010542.4 chr16 66549280 66551189 + AC145207.5 chr17 81878425 81881106 - AC234582.1 chr1 155195004 155205495 + H19 chr11 1995176 2001470 - LINC00240 chr6 26956932 27059749 + MALAT1 chr11 65497688 65506516 + SNHG7 chr9 136721366 136728184 - XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE65203 Sample Source: Breast Milk Source Fraction: Supernatant Platform: GPL7731 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 548 Sample treatment protocol: NA RNA Extract protocol: Total RNA extracted using mirVana miRNA isolation kit following manufacturer's instructions. RNA library preparation protocol: 70 ng of each RNA sample was labeled with the miRNA Complete Labeling Reagent and Hybridization kit (Agilent Technologies) according to the manufacturer's instructions.

Reference

PMID: 20226005 Title: microRNA as a new immune-regulatory agent in breast milk Author: Kosaka N, Izumi H, Sekine K, Ochiya T. Journal: Silence. 2010 Mar 1;1(1):7. Description: BACKGROUND: Breast milk is a complex liquid that provides nutrition to the infant and facilitates the maturation of the infant's immune system. Recent studies indicated that microRNA (miRNA) exists in human body fluid. Because miRNAs are known to regulate various immune systems, we hypothesized that human breast milk contains miRNAs that may be important for the development of the infant's immune system.