Entry Detail



General Information

Database ID:exR0359123
RNA Name:hsa-miR-654-3p
RNA Type:miRNA
Chromosome:chr14
Starnd:+
Coordinate:
Start Site(bp):101040269End Site(bp):101040290
External Links:hsa-miR-654-3p



Disease Information

Disease Name:Newborn Infant
Disease Category:Other Diseases
MeSH ID:D007231
Type:Age Groups/Infant
Alias:Infant, Newborn//Infants, Newborn//Newborn Infant//Newborn Infants//Newborns//Newborn//Neonate//Neonates



Expression Detail

GEO ID:GSE65203
Description:microRNA as a new immune-regulatory agent in breast milk
Experimental Design:Disease vs Control
Case Disease Type:Newborn Infant
Case Disease SubType:NA
Case Sample:Deliver < 28 days
Control Sample:Deliver > 28 days
Number of Case:2
Number of Control:4
Number of Samples:6





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ANKRD49
chr11
94493979
94499578
+
ATAD1
chr10
87751512
87841343
-
CAMTA1
chr1
6785454
7769706
+
CLN8
chr8
1755778
1801711
+
EPB41L1
chr20
36091504
36232799
+
RAB10
chr2
26034084
26137454
+
RNF220
chr1
44405194
44651724
+
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0001146
chr20
34241449
34246936
-
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC005899.4
chr17
32328441
32329395
+
AC079781.5
chr7
97851688
97972985
-
AL049795.2
chr1
32170733
32176568
+
AL358472.3
chr1
153966516
153966930
+
HCG11
chr6
26521709
26527404
+
MCM3AP-AS1
chr21
46229196
46259390
+
NEAT1
chr11
65422774
65445540
+
SNHG1
chr11
62851984
62855953
-
THUMPD3-AS1
chr3
9349689
9398579
-
TUG1
chr22
30969245
30979395
+
XIST
chrX
73820649
73852723
-
ZFAS1
chr20
49278178
49299600
+
Display:



Experiment Detail

GEO ID:GSE65203
Sample Source:Breast Milk
Source Fraction:Supernatant
Platform:GPL7731
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:548
Sample treatment protocol:NA
RNA Extract protocol:Total RNA extracted using mirVana miRNA isolation kit following manufacturer's instructions.
RNA library preparation protocol:70 ng of each RNA sample was labeled with the miRNA Complete Labeling Reagent and Hybridization kit (Agilent Technologies) according to the manufacturer's instructions.



Reference

PMID:20226005
Title:microRNA as a new immune-regulatory agent in breast milk
Author:Kosaka N, Izumi H, Sekine K, Ochiya T.
Journal:Silence. 2010 Mar 1;1(1):7.
Description:BACKGROUND: Breast milk is a complex liquid that provides nutrition to the infant and facilitates the maturation of the infant's immune system. Recent studies indicated that microRNA (miRNA) exists in human body fluid. Because miRNAs are known to regulate various immune systems, we hypothesized that human breast milk contains miRNAs that may be important for the development of the infant's immune system.