exRNAdisease

Entry Detail

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General Information

Database ID: exR0359141 RNA Name: hsa-miR-760 RNA Type: miRNA Chromosome: chr1 Starnd: + Coordinate: Start Site(bp): 93846880 End Site(bp): 93846899 External Links: hsa-miR-760

Disease Information

Disease Name: Newborn Infant Disease Category: Other Diseases MeSH ID: D007231 Type: Age Groups/Infant Alias: Infant, Newborn//Infants, Newborn//Newborn Infant//Newborn Infants//Newborns//Newborn//Neonate//Neonates

Expression Detail

GEO ID: GSE65203 Description: microRNA as a new immune-regulatory agent in breast milk Experimental Design: Disease vs Control Case Disease Type: Newborn Infant Case Disease SubType: NA Case Sample: Deliver < 28 days Control Sample: Deliver > 28 days Number of Case: 2 Number of Control: 4 Number of Samples: 6

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ABL1 chr9 130713016 130887675 + ACVR1B chr12 51951699 51997078 + ARID3B chr15 74541177 74598131 + C6orf89 chr6 36871870 36928964 + CHTF8 chr16 69118010 69132578 - DBNDD1 chr16 90004871 90020128 - DDX54 chr12 113157174 113185479 - DMWD chr19 45782947 45792845 - EFTUD2 chr17 44849948 44899445 - ITGA5 chr12 54395261 54419266 - MEF2D chr1 156463727 156500779 - PDCD6 chr5 271621 314974 + PDE8A chr15 84980440 85139145 + PDXK chr21 43719094 43762307 + RAE1 chr20 57351223 57379211 + SLC35B2 chr6 44254096 44257890 - TELO2 chr16 1493344 1510457 + TSPAN14 chr10 80454166 80533124 + WSB2 chr12 118032694 118062430 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000458 chr12 124071293 124074996 + hsa_circ_0000038 chr1 28800065 28802803 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand KCNQ1OT1 chr11 2608328 2699994 - MALAT1 chr11 65497688 65506516 + MIR194-2HG chr11 64889560 64893449 - NEAT1 chr11 65422774 65445540 + NORAD chr20 36045618 36051018 - SNHG1 chr11 62851984 62855953 - TUG1 chr22 30969245 30979395 + Display:

Experiment Detail

GEO ID: GSE65203 Sample Source: Breast Milk Source Fraction: Supernatant Platform: GPL7731 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 548 Sample treatment protocol: NA RNA Extract protocol: Total RNA extracted using mirVana miRNA isolation kit following manufacturer's instructions. RNA library preparation protocol: 70 ng of each RNA sample was labeled with the miRNA Complete Labeling Reagent and Hybridization kit (Agilent Technologies) according to the manufacturer's instructions.

Reference

PMID: 20226005 Title: microRNA as a new immune-regulatory agent in breast milk Author: Kosaka N, Izumi H, Sekine K, Ochiya T. Journal: Silence. 2010 Mar 1;1(1):7. Description: BACKGROUND: Breast milk is a complex liquid that provides nutrition to the infant and facilitates the maturation of the infant's immune system. Recent studies indicated that microRNA (miRNA) exists in human body fluid. Because miRNAs are known to regulate various immune systems, we hypothesized that human breast milk contains miRNAs that may be important for the development of the infant's immune system.