exRNAdisease

Entry Detail

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General Information

Database ID: exR0359150 RNA Name: hsa-miR-877-5p RNA Type: miRNA Chromosome: chr6 Starnd: + Coordinate: Start Site(bp): 30584332 End Site(bp): 30584351 External Links: hsa-miR-877-5p

Disease Information

Disease Name: Newborn Infant Disease Category: Other Diseases MeSH ID: D007231 Type: Age Groups/Infant Alias: Infant, Newborn//Infants, Newborn//Newborn Infant//Newborn Infants//Newborns//Newborn//Neonate//Neonates

Expression Detail

GEO ID: GSE65203 Description: microRNA as a new immune-regulatory agent in breast milk Experimental Design: Disease vs Control Case Disease Type: Newborn Infant Case Disease SubType: NA Case Sample: Deliver < 28 days Control Sample: Deliver > 28 days Number of Case: 2 Number of Control: 4 Number of Samples: 6

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ABR chr17 1003518 1229738 - DNAJB6 chr7 157335381 157417439 + EIF2AK1 chr7 6022247 6059175 - FOSL1 chr11 65892049 65900573 - IGF2BP1 chr17 48997385 49056145 + MAPK8IP2 chr22 50600793 50613981 + PHTF2 chr7 77798792 77957503 + PLD3 chr19 40348456 40380439 + SMG1 chr16 18804853 18926454 - TRAF7 chr16 2155698 2178129 + USP54 chr10 73497538 73625953 - ANAPC7 chr12 110372900 110403730 - EIF4ENIF1 chr22 31436977 31496108 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC010442.1 chr5 466124 473098 - AC092718.4 chr16 81030770 81031485 + DNAAF4-CCPG1 chr15 55355248 55498360 - DSCAM-AS1 chr21 40383083 40385358 + LINC00910 chr17 43338741 43389199 - LINC01278 chrX 63222993 63561095 - NEAT1 chr11 65422774 65445540 + SNHG16 chr17 76557764 76565348 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE65203 Sample Source: Breast Milk Source Fraction: Supernatant Platform: GPL7731 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 548 Sample treatment protocol: NA RNA Extract protocol: Total RNA extracted using mirVana miRNA isolation kit following manufacturer's instructions. RNA library preparation protocol: 70 ng of each RNA sample was labeled with the miRNA Complete Labeling Reagent and Hybridization kit (Agilent Technologies) according to the manufacturer's instructions.

Reference

PMID: 20226005 Title: microRNA as a new immune-regulatory agent in breast milk Author: Kosaka N, Izumi H, Sekine K, Ochiya T. Journal: Silence. 2010 Mar 1;1(1):7. Description: BACKGROUND: Breast milk is a complex liquid that provides nutrition to the infant and facilitates the maturation of the infant's immune system. Recent studies indicated that microRNA (miRNA) exists in human body fluid. Because miRNAs are known to regulate various immune systems, we hypothesized that human breast milk contains miRNAs that may be important for the development of the infant's immune system.