exRNAdisease

Entry Detail

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General Information

Database ID: exR0359218 RNA Name: ABCC1 RNA Type: mRNA Chromosome: chr16 Starnd: + Coordinate: Start Site(bp): 15949577 End Site(bp): 16143074 External Links: ENSG00000103222

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand TMED2 chr12 123584533 123598582 + PCDHGB6 chr5 141408021 141512979 + ADGRV1 chr5 90529344 91164437 + CENPU chr4 184694085 184734130 - RFC5 chr12 118013588 118033130 + BLVRB chr19 40447765 40465764 - MACF1 chr1 39081316 39487177 + RPS5 chr19 58386400 58394806 + SETD1A chr16 30957754 30984664 + CRTC3 chr15 90529923 90645345 + PCDHGB1 chr5 141350102 141512979 + PCDHGA8 chr5 141390157 141512979 + NUCKS1 chr1 205712822 205750182 - MT-ND4 chrMT 10760 12137 + ASXL1 chr20 32358330 32439319 + STRBP chr9 123109500 123268586 - UBE2S chr19 55399745 55407788 - ZDHHC4 chr7 6577434 6589374 + NOP53 chr19 47745546 47757058 + CD52 chr1 26317958 26320523 + PSMB9 chr6 32844136 32859851 + PCDHGA7 chr5 141382739 141512975 + MT-CYB chrMT 14747 15887 + MT-ND5 chrMT 12337 14148 + PCDHGA6 chr5 141373914 141512979 + PCDHGA5 chr5 141364232 141512979 + EIF4G2 chr11 10797050 10808940 - MT-CO2 chrMT 7586 8269 + SC5D chr11 121292681 121313410 + AC104109.3 chr5 134167170 134226071 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AD000090.1 chr19 35557956 35581954 + AL136419.1 chr14 23969931 24051377 + AC138932.3 chr16 14909887 14911345 - ERVK13-1 chr16 2660348 2682379 - GAS5 chr1 173858559 173868882 - MIR663AHG chr20 26167817 26251546 - SNHG17 chr20 38419638 38435409 - SNHG19 chr16 2154797 2155358 - XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.