exRNAdisease

Entry Detail

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General Information

Database ID: exR0359230 RNA Name: ABCD3 RNA Type: mRNA Chromosome: chr1 Starnd: + Coordinate: Start Site(bp): 94418389 End Site(bp): 94518666 External Links: ENSG00000117528

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand SLC25A6 chrX 1386152 1392113 - RPL13 chr16 89560657 89566828 + ACYP2 chr2 53970838 54305300 + RPL15 chr3 23916545 23924374 + C18orf25 chr18 46173553 46266992 + GFM1 chr3 158644278 158692575 + SH3KBP1 chrX 19533977 19887600 - EGLN2 chr19 40798996 40808434 + MIF chr22 23894383 23895227 + LTA4H chr12 96000753 96043520 - RIC1 chr9 5629025 5776557 + EIF3L chr22 37848868 37889407 + SMIM13 chr6 11093834 11138733 + ZKSCAN8 chr6 28141883 28159460 + NACA chr12 56712427 56731628 - CBX4 chr17 79833156 79839440 - RPS6 chr9 19375715 19380236 - HNRNPR chr1 23303771 23344336 - RPL28 chr19 55385345 55403250 + MYCN chr2 15940550 15947007 + PELP1 chr17 4669774 4704337 - HSP90AA1 chr14 102080738 102139699 - GMPS chr3 155870650 155944020 + COPA chr1 160288594 160343273 - PLEKHO2 chr15 64841883 64868002 + MAP2K4 chr17 12020829 12143830 + LAPTM4B chr8 97775057 97853013 + RBX1 chr22 40951347 40973309 + C11orf24 chr11 68261338 68272001 - CRYL1 chr13 20403666 20525873 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AL022311.1 chr22 37876148 37895563 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.