exRNAdisease

Entry Detail

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General Information

Database ID: exR0359250 RNA Name: ABHD2 RNA Type: mRNA Chromosome: chr15 Starnd: + Coordinate: Start Site(bp): 89087459 End Site(bp): 89202355 External Links: ENSG00000140526

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand NUP210 chr3 13316235 13420322 - RPS21 chr20 62387103 62388520 + RPS6KB2 chr11 67428460 67435401 + MT-ND5 chrMT 12337 14148 + PPIF chr10 79347469 79355334 + BRD2 chr6 32968594 32981505 + MMD chr17 55392622 55421924 - AP3S2 chr15 89830599 89894638 - EEF1A1 chr6 73515750 73523797 - PABPC3 chr13 25095868 25099254 + MKRN1 chr7 140453033 140479536 - AC024592.3 chr19 5866171 5903787 - SHC2 chr19 416583 460996 - DMWD chr19 45782947 45792845 - RPUSD3 chr3 9837849 9844602 - PTGIS chr20 49503874 49568137 - METTL2A chr17 62423867 62450822 + EMC3 chr3 9962537 10011116 - NDUFA11 chr19 5891276 5904006 - KMT2D chr12 49018975 49059774 - CMTM3 chr16 66603874 66613892 + HLA-A chr6 29941260 29945884 + CWC27 chr5 64768930 65018750 + CCDC174 chr3 14651746 14672659 + ATP5F1A chr18 46080248 46104334 - RNF40 chr16 30761745 30776307 + MACF1 chr1 39081316 39487177 + HOXD4 chr2 176151550 176153226 + TSSC4 chr11 2400488 2403878 + SALL2 chr14 21521080 21537216 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-15a-5p chr13 50049167 50049188 - hsa-miR-103a-3p chr5 168560904 168560926 - hsa-miR-107 chr10 89592756 89592778 - hsa-miR-214-3p chr1 172138816 172138837 - hsa-miR-15b-5p chr3 160404607 160404628 + hsa-miR-195-5p chr17 7017667 7017687 - hsa-miR-497-5p chr17 7017979 7017999 - hsa-miR-423-5p chr17 30117095 30117117 + hsa-miR-532-3p chrX 50003204 50003225 + hsa-miR-541-3p chr14 101064548 101064569 + hsa-miR-665 chr14 100875075 100875094 + hsa-miR-873-5p chr9 28888925 28888945 - hsa-miR-1294 chr5 154347153 154347174 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC067930.1 chr8 143579636 143580670 + AC104257.1 chr8 131308545 131317632 + AC079949.1 chr12 127142029 127146532 - MUC20-OT1 chr3 195658062 195739964 + SNAI3-AS1 chr16 88663298 88687278 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.