exRNAdisease

Entry Detail

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General Information

Database ID: exR0359252 RNA Name: ABHD5 RNA Type: mRNA Chromosome: chr3 Starnd: + Coordinate: Start Site(bp): 43690108 End Site(bp): 43734371 External Links: ENSG00000011198

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand KIAA1143 chr3 44737661 44761619 - RPLP1 chr15 69452814 69456205 + LGALS3BP chr17 78971238 78979947 - ATF7IP chr12 14365632 14502935 + TOMM22 chr22 38681957 38685421 + TIAF1 chr17 29073521 29078857 - TMSB4X chrX 12975110 12977227 + NIPSNAP1 chr22 29554808 29581327 - DCAF10 chr9 37800554 37867666 + ZFAT chr8 134477788 134713049 - THOC5 chr22 29505879 29555216 - CNN2 chr19 1026586 1039068 + GALNT2 chr1 230057990 230282122 + MYO18A chr17 29071124 29180412 - PLBD2 chr12 113358566 113391629 + HS3ST3B1 chr17 14301081 14349404 + TUBB4B chr9 137241287 137243707 + RPL18A chr19 17859910 17864153 + TUBB chr6 30720352 30725426 + AC010422.3 chr19 12643831 12648397 - CBSL chr21 6444869 6468040 - ATP5MC3 chr2 175176258 175184607 - CBS chr21 43053191 43076943 - ANO10 chr3 43354859 43691594 - ZNF75D chrX 135248920 135344109 - SEH1L chr18 12947133 12987536 + DICER1 chr14 95086228 95158010 - GDI1 chrX 154436913 154443467 + PTMA chr2 231706895 231713541 + HSD17B4 chr5 119452473 119637199 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand U73166.1 chr3 50260303 50263358 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.