exRNAdisease

Entry Detail

---



General Information

Database ID: exR0359254 RNA Name: ABI1 RNA Type: mRNA Chromosome: chr10 Starnd: - Coordinate: Start Site(bp): 26746593 End Site(bp): 26861087 External Links: ENSG00000136754

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand B2M chr15 44711487 44718877 + RPS27L chr15 63125872 63158021 - MTRNR2L1 chr17 22523111 22524663 + PSMB1 chr6 170535120 170553307 - COPG1 chr3 129249606 129277773 + TTF1 chr9 132375548 132406851 - TCEA1 chr8 53966552 54022456 - AGK chr7 141551278 141655244 + WAC chr10 28532493 28623112 + ACLY chr17 41866917 41930542 - SUMO3 chr21 44805617 44818779 - LARP1 chr5 154712843 154817605 + IL10RB chr21 33266367 33310187 + RNF125 chr18 32018825 32073219 + AFF1 chr4 86935002 87141054 + PTMS chr12 6765516 6770952 + UBE3C chr7 157138916 157269370 + THOP1 chr19 2785503 2815807 + SLC30A5 chr5 69093949 69131069 + KIF23 chr15 69414246 69448427 + PAN3 chr13 28138506 28295335 + CCT4 chr2 61868085 61888671 - BUB1 chr2 110637528 110678063 - MTHFD2 chr2 74198610 74217565 + ARID1A chr1 26693236 26782104 + TAF10 chr11 6606294 6612539 - MYO19 chr17 36495633 36543435 - SRRM2 chr16 2752626 2772538 + SRPK1 chr6 35832966 35921342 - RPLP1 chr15 69452814 69456205 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC091564.7 chr11 6610883 6616594 - AL158066.1 chr13 52167709 52291557 - AL355075.4 chr14 20343048 20343685 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.