exRNAdisease

Entry Detail

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General Information

Database ID: exR0359258 RNA Name: ABL1 RNA Type: mRNA Chromosome: chr9 Starnd: + Coordinate: Start Site(bp): 130713016 End Site(bp): 130887675 External Links: ENSG00000097007

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand CXCL12 chr10 44370165 44386493 - ASXL2 chr2 25733753 25878487 - TMEM115 chr3 50354750 50359521 - STK11 chr19 1177558 1228431 + TMEM214 chr2 27032910 27041694 + NOP53 chr19 47745546 47757058 + TSC2 chr16 2047967 2089491 + CHTOP chr1 153633982 153646306 + ZMYM3 chrX 71239624 71255146 - NUTF2 chr16 67846923 67872567 + DBNDD2 chr20 45406057 45410610 + PCGF2 chr17 38733898 38749817 - TM9SF3 chr10 96518110 96587452 - CHD4 chr12 6570082 6614524 - AP000350.4 chr22 23862188 23895223 + PLCG1 chr20 41136960 41196801 + ACTB chr7 5527148 5563784 - ATE1 chr10 121740421 121928801 - TSPAN6 chrX 100627108 100639991 - TRAF2 chr9 136881912 136926607 + HMGN4 chr6 26538366 26546933 + ETS2 chr21 38805183 38824955 + LAMP5 chr20 9514358 9530524 + MOV10 chr1 112673141 112700746 + GLUL chr1 182381704 182392206 - TPM4 chr19 16067021 16103002 + SIGIRR chr11 405716 417455 - HNRNPD chr4 82352498 82374503 - CORO7 chr16 4354542 4425705 - ZNF319 chr16 57994668 58000453 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-432-5p chr14 100884496 100884518 + hsa-miR-520a-5p chr19 53690895 53690915 + hsa-miR-650 chr22 22822791 22822811 + hsa-miR-330-5p chr19 45639049 45639070 - hsa-miR-760 chr1 93846880 93846899 + hsa-miR-1270 chr19 20399320 20399342 - circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC007993.3 chr17 43914433 43923001 - AC069281.2 chr7 100572232 100578700 - NEAT1 chr11 65422774 65445540 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.