exRNAdisease

Entry Detail

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General Information

Database ID: exR0359274 RNA Name: ACAD10 RNA Type: mRNA Chromosome: chr12 Starnd: + Coordinate: Start Site(bp): 111686056 End Site(bp): 111757107 External Links: ENSG00000111271

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand NDUFA10 chr2 239892450 240025345 - GPCPD1 chr20 5544439 5611006 - IPP chr1 45694324 45750653 - MRM2 chr7 2234195 2242205 - SLAMF6 chr1 160485030 160523262 - MYH9 chr22 36281277 36388067 - SLC52A2 chr8 144354135 144361272 + CPT1C chr19 49690898 49713731 + PSMD11 chr17 32444379 32483319 + HMGB2 chr4 173331376 173334432 - SP110 chr2 230167293 230225729 - CBX3 chr7 26201162 26213607 + DNAJC25 chr9 111631334 111654351 + PTP4A3 chr8 141391995 141432454 + CMTR1 chr6 37433219 37482827 + PLXNA1 chr3 126988594 127037392 + ZBED4 chr22 49853844 49890080 + ST8SIA1 chr12 22063773 22437041 - ACTN1 chr14 68874143 68979440 - UBE2Z chr17 48908407 48929056 + GRK2 chr11 67266473 67286556 + DCTN2 chr12 57530102 57547331 - FOXM1 chr12 2857681 2877155 - MT-ND1 chrMT 3307 4262 + VIPAS39 chr14 77426675 77457952 - EPM2AIP1 chr3 36985043 36993131 - ST6GAL1 chr3 186930502 187078553 + TPGS2 chr18 36777647 36829216 - AL132780.3 chr14 22946270 22982258 - FSCN3 chr7 127591409 127602144 + miRNA targets: NA circRNA targets: NA lncRNA targets: NA Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.