exRNAdisease

Entry Detail

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General Information

Database ID: exR0359276 RNA Name: ACAD8 RNA Type: mRNA Chromosome: chr11 Starnd: + Coordinate: Start Site(bp): 134253495 End Site(bp): 134265855 External Links: ENSG00000151498

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand CALR chr19 12938578 12944489 + PPA1 chr10 70202835 70233911 - YBX1 chr1 42682418 42703805 + COMMD1 chr2 61888724 62147247 + DCTD chr4 182890060 182917936 - NCK1 chr3 136862208 136951606 + SOS1 chr2 38981549 39124345 - MT-CO3 chrMT 9207 9990 + GSTP1 chr11 67583742 67586656 + PTPRCAP chr11 67435510 67437682 - GTF2A2 chr15 59638062 59657541 - ZNF585B chr19 37181579 37218153 - PGM2 chr4 37826660 37862937 + TBC1D2B chr15 77984036 78077724 - RPS27A chr2 55231903 55235853 + SMARCB1 chr22 23786931 23838008 + MZT2A chr2 131464900 131492743 - CORO1B chr11 67435510 67443821 - SEC62 chr3 169966635 169998373 + TRIM71 chr3 32817997 32897824 + PSMD9 chr12 121888732 121918297 + CCDC86 chr11 60842113 60851081 + PBX1 chr1 164555584 164899296 + VPS26B chr11 134224671 134247788 + ATRAID chr2 27212027 27217178 + EEF1G chr11 62559596 62574086 - PODXL chr7 131500262 131558217 - RPL29 chr3 51993522 51995895 - ISG15 chr1 1001138 1014540 + PDP1 chr8 93857807 93926068 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand BOLA3-AS1 chr2 74148007 74151952 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.