exRNAdisease

General Information

Database ID:

exR0359296

RNA Name:

ACHE

RNA Type:

mRNA

Chromosome:

chr7

Starnd:

Coordinate:

Start Site(bp):

100889994

End Site(bp):

100896974

External Links:

Disease Information

Disease Name:	Amyotrophic Lateral Sclerosis
Disease Category:	Nervous System Diseases
MeSH ID:	D000690
Type:	Diseases Category/Nervous System Diseases
Alias:	Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID:	GSE121519
Description:	Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid.
Experimental Design:	Disease vs Control
Case Disease Type:	Amyotrophic Lateral Sclerosis
Case Disease SubType:	NA
Case Sample:	Amyotrophic Lateral Sclerosis
Control Sample:	Healthy
Number of Case:	4
Number of Control:	4
Number of Samples:	8

Regulatory Relationship

mRNA targets:

Gene Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
CPNE2	chr16	57092583	57148369	+
GNAI2	chr3	50226292	50259362	+
GOLGA7	chr8	41490396	41510980	+
GORASP1	chr3	39096659	39108363	-
HLA-A	chr6	29941260	29945884	+
PCDHGA1	chr5	141330571	141512981	+
PCDHGA10	chr5	141412987	141512979	+
PCDHGA11	chr5	141421047	141512975	+
PCDHGA12	chr5	141430507	141512975	+
PCDHGA2	chr5	141338760	141512975	+
PCDHGA3	chr5	141343829	141512979	+
PCDHGA4	chr5	141355021	141512975	+
PCDHGA5	chr5	141364232	141512979	+
PCDHGA6	chr5	141373914	141512979	+
PCDHGA7	chr5	141382739	141512975	+
PCDHGA8	chr5	141390157	141512979	+
PCDHGA9	chr5	141402932	141512979	+
PCDHGB1	chr5	141350102	141512979	+
PCDHGB2	chr5	141360042	141512979	+
PCDHGB3	chr5	141370242	141512975	+
PCDHGB4	chr5	141387698	141512979	+
PCDHGB5	chr5	141397987	141512979	+
PCDHGB6	chr5	141408021	141512979	+
PCDHGB7	chr5	141417645	141512979	+
PCDHGC3	chr5	141475947	141512977	+
PCDHGC4	chr5	141484997	141512979	+
PCDHGC5	chr5	141489121	141512979	+
PLD3	chr19	40348456	40380439	+
UBQLN1	chr9	83659968	83707958	-
UQCRHL	chr1	15807169	15809348	-

miRNA targets:

circRNA targets:

lncRNA targets:

Display:

Experiment Detail

GEO ID:	GSE121519
Sample Source:	Cerebrospinal Fluid
Source Fraction:	Exosome
Platform:	GPL18573
Method:	NGS
Num of detected RNA Type:	2
Num of detected RNAs of this Type:	17787
Sample treatment protocol:	Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant.
RNA Extract protocol:	Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted.
RNA library preparation protocol:	Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID:	30630471
Title:	Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid
Author:	Otake K, Kamiguchi H, Hirozane Y
Journal:	BMC Med Genomics. 2019 Jan 10;12(1):7.
Description:	The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.