exRNAdisease

Entry Detail

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General Information

Database ID: exR0359297 RNA Name: ACIN1 RNA Type: mRNA Chromosome: chr14 Starnd: - Coordinate: Start Site(bp): 23058564 End Site(bp): 23095614 External Links: ENSG00000100813

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand HNRNPA2B1 chr7 26173057 26201529 - CD74 chr5 150400041 150412929 - EEF1G chr11 62559596 62574086 - MANEAL chr1 37793802 37801137 + CGN chr1 151510510 151538692 + LRRC58 chr3 120324509 120349354 - RGPD5 chr2 109792758 109857705 + IVNS1ABP chr1 185296388 185317273 - TTLL3 chr3 9808086 9855138 + SDHAF3 chr7 97117698 97181763 + JAGN1 chr3 9890574 9894349 + RPL39 chrX 119786504 119791630 - CFAP20 chr16 58113592 58129381 - PCDHGA3 chr5 141343829 141512979 + PCDHGA1 chr5 141330571 141512981 + ALDH7A1 chr5 126531200 126595362 - EEF1A1 chr6 73515750 73523797 - PMF1 chr1 156212993 156240042 + WWC3 chrX 10015562 10144478 + RACK1 chr5 181236897 181248096 - SFXN1 chr5 175477062 175529742 + TPT1 chr13 45333471 45341370 - MRPS7 chr17 75261674 75266376 + RNASEK chr17 7012417 7014532 + TRAF7 chr16 2155698 2178129 + CERK chr22 46684410 46738252 - TSC2 chr16 2047967 2089491 + CNP chr17 41966763 41977740 + RPL11 chr1 23691742 23696835 + PCDHGA10 chr5 141412987 141512979 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC027682.2 chr16 67542123 67542963 - AC124068.2 chr15 89335053 89336161 + AL132780.1 chr14 22929607 22956374 + AL355075.4 chr14 20343048 20343685 - AP001496.2 chr18 5232876 5238526 - AP005263.1 chr18 9102736 9254346 + BISPR chr19 17405686 17419324 + NEAT1 chr11 65422774 65445540 + XIST chrX 73820649 73852723 - Z83843.1 chrX 74209976 74213660 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.