exRNAdisease

Entry Detail

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General Information

Database ID: exR0359306 RNA Name: ACOT9 RNA Type: mRNA Chromosome: chrX Starnd: - Coordinate: Start Site(bp): 23701055 End Site(bp): 23766475 External Links: ENSG00000123130

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand CALM2 chr2 47160083 47176921 - NKX1-2 chr10 124445243 124450035 - PKP3 chr11 392614 404908 + GDI2 chr10 5765223 5842132 - RPLP1 chr15 69452814 69456205 + TTLL3 chr3 9808086 9855138 + KPNA5 chr6 116681187 116741867 + PKN2 chr1 88684222 88836255 + PLEKHB2 chr2 131104847 131353709 + AIP chr11 67483026 67491103 + MT-CO2 chrMT 7586 8269 + NUP155 chr5 37288137 37371106 - PIEZO1 chr16 88715338 88785220 - N4BP2L2 chr13 32432417 32538885 - OCLN chr5 69492292 69558104 + CEP55 chr10 93496612 93529092 + HLA-C chr6 31268749 31272130 - PNPO chr17 47941506 47949308 + MYDGF chr19 4641374 4670362 - SSBP1 chr7 141738334 141787922 + NECAP2 chr1 16440721 16460078 + RPS16 chr19 39433137 39435949 - HMGCS1 chr5 43287470 43313512 - DICER1 chr14 95086228 95158010 - ANKRD46 chr8 100509752 100559784 - PCBP1 chr2 70087477 70089203 + PHTF2 chr7 77798792 77957503 + RGS1 chr1 192575763 192580024 + ADNP chr20 50888916 50931437 - CD74 chr5 150400041 150412929 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand JPX chrX 73944182 74070408 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.