exRNAdisease

Entry Detail

---



General Information

Database ID: exR0359307 RNA Name: ACOX1 RNA Type: mRNA Chromosome: chr17 Starnd: - Coordinate: Start Site(bp): 75941507 End Site(bp): 75979177 External Links: ENSG00000161533

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand RPS19 chr19 41860255 41872925 + SAP18 chr13 21140514 21149084 + LAMA3 chr18 23689443 23956222 + ZNF512 chr2 27582969 27623217 + ELAC2 chr17 12991612 13018065 - C3orf52 chr3 112086335 112131004 + MAZ chr16 29806106 29811164 + POU5F1 chr6 31164337 31180731 - ZNF544 chr19 58228594 58277495 + NUP205 chr7 135557917 135648757 + OPA1 chr3 193593144 193697811 + KIF14 chr1 200551497 200620751 - WDR26 chr1 224385143 224437033 - ELF4 chrX 130064874 130110716 - ASXL1 chr20 32358330 32439319 + NRF1 chr7 129611720 129757082 + SMC3 chr10 110567691 110604636 + OSBPL10 chr3 31657890 32077580 - PSAP chr10 71816298 71851325 - TOX4 chr14 21476597 21499175 + PPP6R1 chr19 55229779 55259017 - RPL13A chr19 49487554 49492308 + TNFRSF13B chr17 16929816 16972118 - MREG chr2 215942584 216034096 - NDUFV1 chr11 67605653 67612554 + PPM1G chr2 27381195 27409591 - HLA-A chr6 29941260 29945884 + NOP14 chr4 2937933 2963406 - DCTPP1 chr16 30423615 30430030 - RPL10L chr14 46651010 46651781 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC138761.1 chr17 22266395 22288301 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.