exRNAdisease

Entry Detail

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General Information

Database ID: exR0359312 RNA Name: ACP6 RNA Type: mRNA Chromosome: chr1 Starnd: - Coordinate: Start Site(bp): 147629652 End Site(bp): 147670524 External Links: ENSG00000162836

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ABHD12 chr20 25294742 25390835 - ACSL1 chr4 184755595 184826818 - BICD2 chr9 92711363 92764833 - CHERP chr19 16517894 16542437 - CHRNB1 chr17 7445061 7457710 + COX4I1 chr16 85798633 85807068 + CPSF1 chr8 144393229 144409335 - DERL3 chr22 23834503 23839128 - DST chr6 56457987 56954649 - FBXO4 chr5 41925254 41941743 + GDE1 chr16 19501693 19522123 - GLCE chr15 69160584 69272217 + GLIS3 chr9 3824127 4348392 - IFITM1 chr11 313506 315272 + IFITM2 chr11 307631 315272 + NUP214 chr9 131125586 131234663 + PARP14 chr3 122680839 122730840 + PCNA chr20 5114953 5126626 - PHF21B chr22 44881162 45010005 - PKM chr15 72199029 72231822 - PPRC1 chr10 102132994 102150333 + RPL11 chr1 23691742 23696835 + RPL5 chr1 92832013 92841924 + SCD chr10 100347233 100364826 + TGFBRAP1 chr2 105264391 105329735 - TRAM2 chr6 52497408 52577060 - TUBG2 chr17 42659284 42667006 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC113189.4 chr17 7439506 7445966 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.