exRNAdisease

Entry Detail

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General Information

Database ID: exR0359319 RNA Name: ACSL3 RNA Type: mRNA Chromosome: chr2 Starnd: + Coordinate: Start Site(bp): 222860942 End Site(bp): 222944639 External Links: ENSG00000123983

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand BCORL1 chrX 129981107 130058083 + GANAB chr11 62624826 62646726 - TMA7 chr3 48440257 48444208 + TPMT chr6 18128311 18155077 - EIF1B chr3 40309707 40312424 + AIFM1 chrX 130129362 130165887 - IRX3 chr16 54283304 54286787 - OTUD1 chr10 23439458 23442390 + VASN chr16 4371848 4383538 + TTC37 chr5 95461755 95555007 - EP300 chr22 41092592 41180077 + NSUN4 chr1 46340177 46365152 + MED1 chr17 39404285 39451272 - MAGT1 chrX 77826364 77895593 - EEF2 chr19 3976056 3985463 - ZWILCH chr15 66504959 66550130 + RPL7L1 chr6 42879616 42889925 + AP001781.2 chr11 111786286 111879425 - RPS7 chr2 3575260 3580920 + TUBA1A chr12 49184795 49189080 - SMARCC1 chr3 47585269 47782106 - DDX39B chr6 31530219 31542448 - IQSEC1 chr3 12897043 13283281 - DBN1 chr5 177456608 177474401 - MRFAP1 chr4 6640091 6642745 + ISCA1 chr9 86264546 86283102 - GNA12 chr7 2728105 2844308 - INTS13 chr12 26905181 26938326 - DMXL2 chr15 51447711 51622833 - CD47 chr3 108043091 108091862 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC010733.2 chr2 60925909 60931610 + AC245033.2 chr15 82540870 82562374 + LINC00836 chr10 25651712 25732935 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.