exRNAdisease

Entry Detail

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General Information

Database ID: exR0359320 RNA Name: ACSL4 RNA Type: mRNA Chromosome: chrX Starnd: - Coordinate: Start Site(bp): 109624244 End Site(bp): 109733403 External Links: ENSG00000068366

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand CEP78 chr9 78236062 78279690 + RPL23 chr17 38847860 38853764 - ADGRL1 chr19 14147743 14206187 - LRBA chr4 150264435 151015727 - ACOT2 chr14 73567620 73575658 + COX8A chr11 63974620 63976543 + PITPNC1 chr17 67377281 67697261 + BEX5 chrX 102153708 102155977 - NUDT21 chr16 56429133 56452199 - NUCKS1 chr1 205712822 205750182 - BHLHE40 chr3 4979437 4985323 + ZMYM4 chr1 35268709 35422058 + KCNE5 chrX 109623700 109625172 - C9orf40 chr9 74946583 74952912 - CPZ chr4 8592660 8619759 + MZT2A chr2 131464900 131492743 - ENO1 chr1 8861000 8879190 - ARPC5 chr1 183620846 183635783 - ZMAT2 chr5 140698680 140706686 + MKNK2 chr19 2037465 2051244 - MTRNR2L1 chr17 22523111 22524663 + HELQ chr4 83407343 83455855 - GAPDH chr12 6534512 6538374 + FOXRED1 chr11 126269055 126278131 + KRAS chr12 25205246 25250936 - TIMM17B chrX 48893447 48898143 - COPB2 chr3 139355600 139389680 - UBL7 chr15 74445977 74461182 - CDS2 chr20 5126879 5197887 + EFTUD2 chr17 44849948 44899445 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-34a-5p chr1 9151735 9151756 - hsa-miR-34c-5p chr11 111513451 111513473 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC106864.1 chr4 112693047 112706810 - AL117378.1 chr6 131901963 131920565 + AP003175.1 chr11 75069243 75096964 - NEAT1 chr11 65422774 65445540 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.