exRNAdisease

Entry Detail

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General Information

Database ID: exR0359399 RNA Name: ADAR RNA Type: mRNA Chromosome: chr1 Starnd: - Coordinate: Start Site(bp): 154582057 End Site(bp): 154628013 External Links: ENSG00000160710

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand KIAA0040 chr1 175156986 175192999 - HLA-B chr6 31269491 31357188 - AC007192.1 chr19 18153158 18178117 + TMSB4X chrX 12975110 12977227 + NTAN1 chr16 15037854 15056079 - RPS14 chr5 150442635 150449739 - CLCN6 chr1 11806096 11848079 + KAT7 chr17 49788681 49835026 + SIK3 chr11 116843402 117098437 - TMEM147 chr19 35545600 35547526 + MAN2C1 chr15 75355207 75368612 - LPXN chr11 58526871 58578220 - AURKB chr17 8204733 8210600 - SSR1 chr6 7268306 7347446 - DHCR24 chr1 54849627 54887195 - RPS8 chr1 44775251 44778779 + ATP5PF chr21 25716503 25735673 - RPL27A chr11 8682788 8714759 + TMEM69 chr1 45688181 45694436 + TMED10 chr14 75131469 75176612 - PACSIN2 chr22 42835412 43015149 - UFM1 chr13 38349849 38363619 + OAS3 chr12 112938444 112973251 + SRC chr20 37344685 37406050 + ERP29 chr12 112013348 112023449 + HLA-DPA1 chr6 33064569 33080775 - ZFR chr5 32354350 32444740 - CAPRIN1 chr11 34051731 34102610 + PKM chr15 72199029 72231822 - STARD7 chr2 96184859 96208825 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-130b-3p chr22 21653354 21653375 + hsa-miR-373-3p chr19 53788748 53788770 + hsa-miR-520e-3p chr19 53675764 53675784 + hsa-miR-519c-3p chr19 53686522 53686543 + hsa-miR-519b-3p chr19 53695263 53695284 + hsa-miR-520b-3p chr19 53701267 53701287 + hsa-miR-520c-3p chr19 53707506 53707527 + hsa-miR-4426 chr1 192716333 192716349 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC009163.4 chr16 75458252 75460017 - AC135178.2 chr17 8318088 8318712 - AL139819.1 chr10 100335563 100346390 - LHFPL3-AS2 chr7 104894628 104926645 - LINC01273 chr20 50171809 50176676 + RMST chr12 97430884 97598415 + THAP7-AS1 chr22 21001886 21010342 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.