exRNAdisease

Entry Detail

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General Information

Database ID: exR0359431 RNA Name: ADK RNA Type: mRNA Chromosome: chr10 Starnd: + Coordinate: Start Site(bp): 74151202 End Site(bp): 74709963 External Links: ENSG00000156110

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand CLTC chr17 59619689 59696956 + CORO1C chr12 108645109 108731596 - BCL2L1 chr20 31664452 31723989 - C12orf57 chr12 6942978 6946003 + IFI6 chr1 27666064 27672198 - RAB11FIP3 chr16 425649 523011 + GDI2 chr10 5765223 5842132 - GRWD1 chr19 48445841 48457022 + BCKDHA chr19 41397808 41425002 + DGKZ chr11 46332905 46380554 + IGF2 chr11 2129112 2141238 - PRMT1 chr19 49675786 49689029 + GJA1 chr6 121435595 121449727 + KRT19 chr17 41523617 41528308 - HLA-DPA1 chr6 33064569 33080775 - EIF3E chr8 108201216 108435333 - INO80B-WBP1 chr2 74455088 74460884 + TRIO chr5 14143342 14532128 + MTRNR2L8 chr11 10507894 10509186 - PTPN1 chr20 50510321 50585241 + ZNF664 chr12 123971845 124015439 + MRPL35 chr2 86199355 86213790 + CCNG1 chr5 163437569 163446151 + STAU1 chr20 49113339 49188367 - NBEAL1 chr2 203014879 203226378 + HMGN3 chr6 79201245 79234738 - RPS27L chr15 63125872 63158021 - ENO1 chr1 8861000 8879190 - UBE2J2 chr1 1253909 1273885 - TMED7 chr5 115613210 115632992 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC007952.4 chr17 19112000 19112636 - AC132217.1 chr11 2129121 2129964 - AD000090.1 chr19 35557956 35581954 + IGF2-AS chr11 2140501 2148666 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.