exRNAdisease

Entry Detail

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General Information

Database ID: exR0359432 RNA Name: ADM RNA Type: mRNA Chromosome: chr11 Starnd: + Coordinate: Start Site(bp): 10305073 End Site(bp): 10307397 External Links: ENSG00000148926

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand RASIP1 chr19 48720585 48740610 - YWHAG chr7 76326799 76358991 - SCRIB chr8 143790920 143815773 - CARHSP1 chr16 8852942 8869012 - FAU chr11 65120630 65122177 - DOLK chr9 128945530 128947603 - TMEM39B chr1 32072031 32102866 + ATP13A3 chr3 194402672 194498364 - PIEZO1 chr16 88715338 88785220 - MCUB chr4 109560209 109688719 + SSR2 chr1 156009048 156020951 - ARPC3 chr12 110434823 110450422 - PSMC4 chr19 39971165 39981764 + THOC3 chr5 175917873 176034680 - PRELID3B chr20 59033145 59042809 - CBX3 chr7 26201162 26213607 + SNX19 chr11 130875436 130916509 - STAT1 chr2 190908460 191020960 - HSP90AB1 chr6 44246166 44253888 + PSMF1 chr20 1113240 1189415 + COQ10A chr12 56266858 56270966 + SRSF7 chr2 38743599 38751494 - DDIT4 chr10 72273924 72276036 + OSGIN2 chr8 89901849 89927888 + IRS4 chrX 108732482 108736409 - CENPP chr9 92325953 92620529 + LCMT1 chr16 25111731 25178231 + PACS1 chr11 66070272 66244744 + ATP1B3 chr3 141876124 141926549 + EPS15 chr1 51354263 51519266 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-92a-3p chrX 134169544 134169565 - hsa-miR-363-3p chrX 134169382 134169403 - hsa-miR-367-3p chr4 112647877 112647898 - hsa-miR-92b-3p chr1 155195237 155195258 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC069281.2 chr7 100572232 100578700 - AC073111.3 chr7 150379329 150410597 + PAUPAR chr11 31812307 32002405 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.