exRNAdisease

Entry Detail

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General Information

Database ID: exR0359434 RNA Name: ADNP RNA Type: mRNA Chromosome: chr20 Starnd: - Coordinate: Start Site(bp): 50888916 End Site(bp): 50931437 External Links: ENSG00000101126

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand HNRNPA3 chr2 177212563 177223958 + GRPEL1 chr4 7058895 7068064 - SNRPA chr19 40750637 40765389 + IL9R chrX 155997581 156010817 + RPLP0 chr12 120196699 120201235 - COG8 chr16 69320140 69339667 - CREBRF chr5 173056352 173139284 + RREB1 chr6 7107597 7251980 + LMO2 chr11 33858576 33892076 - HDGF chr1 156742109 156766925 - TUBA1B chr12 49127782 49131397 - ZFAND3 chr6 37819727 38154624 + CUL9 chr6 43182184 43224587 + SLC39A10 chr2 195575977 195737702 + GATD1 chr11 767220 777488 - POLR2B chr4 56977722 57031158 + HPS5 chr11 18278668 18322198 - KDM3B chr5 138352685 138437028 + CCT3 chr1 156308968 156367873 - ACOT9 chrX 23701055 23766475 - MTCH1 chr6 36968141 36986298 - LRP11 chr6 149818757 149864359 - LMAN1 chr18 59327823 59359265 - EIF4E2 chr2 232550674 232583644 + CBL chr11 119206298 119313926 + ATP5MC3 chr2 175176258 175184607 - C18orf25 chr18 46173553 46266992 + MAP7D1 chr1 36155579 36180849 + HMGA1 chr6 34236873 34246231 + PRMT3 chr11 20387558 20509338 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-17-5p chr13 91350618 91350640 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC023509.1 chr12 53441741 53467528 + AJ271736.1 chrX 156004218 156022236 + AC079949.1 chr12 127142029 127146532 - MALAT1 chr11 65497688 65506516 + MIR17HG chr13 91347820 91354579 + TUG1 chr22 30969245 30979395 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.