exRNAdisease

Entry Detail

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General Information

Database ID: exR0359435 RNA Name: ADNP2 RNA Type: mRNA Chromosome: chr18 Starnd: + Coordinate: Start Site(bp): 80109262 End Site(bp): 80147523 External Links: ENSG00000101544

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand PWP2 chr21 44107373 44131181 + USP14 chr18 158383 214629 + ERBB2 chr17 39687914 39730426 + EEF2 chr19 3976056 3985463 - MT-ND2 chrMT 4470 5511 + RPL26 chr17 8377516 8383213 - TOM1L2 chr17 17843511 17972422 - DSC2 chr18 31058840 31102522 - ARID4B chr1 235131634 235328219 - FBXO42 chr1 16246840 16352480 - PEBP1 chr12 118136124 118145584 + CDC42EP3 chr2 37641882 37738468 - NOMO3 chr16 16232528 16294811 + PTMA chr2 231706895 231713541 + ACTA2 chr10 88935074 88991339 - ACTB chr7 5527148 5563784 - PRKCI chr3 170222424 170305977 + TOMM70 chr3 100363431 100401089 - FP565260.1 chr21 5130871 5154658 - RPS20 chr8 56067295 56074581 - SH3GLB1 chr1 86704570 86748184 + GRID2IP chr7 6497462 6551436 - COL4A2 chr13 110305812 110513209 + PGP chr16 2211593 2214840 - CERS6 chr2 168455862 168775137 + NAP1L1 chr12 76036585 76084958 - ALDOA chr16 30064164 30070457 + RPA2 chr1 27891524 27914746 - ITM2C chr2 230864639 230879248 + CALR chr19 12938578 12944489 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-4508 chr15 23562107 23562123 - circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC007218.1 chr16 9666885 9676843 - AC135178.2 chr17 8318088 8318712 - AL391294.1 chrX 81000150 81004217 - HOXA-AS2 chr7 27107777 27134302 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.