exRNAdisease

Entry Detail

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General Information

Database ID: exR0359436 RNA Name: ADO RNA Type: mRNA Chromosome: chr10 Starnd: + Coordinate: Start Site(bp): 62804720 End Site(bp): 62808479 External Links: ENSG00000181915

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand B3GNT10 chr9 120792403 120799918 + PTMA chr2 231706895 231713541 + ANAPC15 chr11 72106378 72112780 - ZNF581 chr19 55635459 55645623 + MTRNR2L12 chr3 96617188 96618236 - RPS11 chr19 49496365 49499708 + UBR5 chr8 102252273 102412759 - TRAPPC4 chr11 119018763 119025454 + NOL11 chr17 67717931 67744531 + GDI2 chr10 5765223 5842132 - GUF1 chr4 44678420 44700928 + XPOT chr12 64404392 64451125 + YWHAQ chr2 9583967 9630997 - E2F5 chr8 85177154 85217158 + RPS17 chr15 82536750 82540459 - MBTD1 chr17 51177425 51260163 - GNAI3 chr1 109548615 109600195 + NEK9 chr14 75079353 75127344 - RPS15 chr19 1438358 1440494 + GRIK2 chr6 101181257 102070083 + PRRC2A chr6 31620715 31637771 + DMTF1 chr7 87152361 87196337 + ERI3 chr1 44221070 44355260 - TSN chr2 121737103 121767853 + ADK chr10 74151202 74709963 + MFGE8 chr15 88898683 88913381 - UBE2G2 chr21 44768580 44801826 - HERPUD2 chr7 35632659 35695571 - CREG1 chr1 167529117 167553805 - HMGA1 chr6 34236873 34246231 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC009163.4 chr16 75458252 75460017 - KANSL1-AS1 chr17 46193576 46196723 + MALAT1 chr11 65497688 65506516 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.