exRNAdisease

Entry Detail

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General Information

Database ID: exR0359442 RNA Name: ADPRHL2 RNA Type: mRNA Chromosome: chr1 Starnd: + Coordinate: Start Site(bp): 36088892 End Site(bp): 36093932 External Links: ENSG00000116863

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand RPS6KL1 chr14 74903951 74923302 - VDAC2 chr10 75210154 75231448 + MT-ND3 chrMT 10059 10404 + ANAPC1 chr2 111611639 111884690 - TESC chr12 117038923 117099479 - HCFC2 chr12 104064531 104106524 + ATP5F1B chr12 56638175 56645984 - SRRT chr7 100875103 100888664 + CDK4 chr12 57747727 57756013 - RAB14 chr9 121178133 121223014 - OXSM chr3 25782917 25794534 + OAZ2 chr15 64687573 64703281 - CA12 chr15 63321378 63381846 - TTC28 chr22 27978014 28679865 - MIGA1 chr1 77779624 77879539 + CPZ chr4 8592660 8619759 + MCM5 chr22 35400134 35425431 + BRWD1 chr21 39184176 39321559 - IDI1 chr10 1039152 1049170 - STX16 chr20 58651253 58679526 + HLA-DQB1 chr6 32659467 32668383 - TNFRSF1A chr12 6328757 6342114 - STRAP chr12 15882387 15903478 + HLA-B chr6 31269491 31357188 - SPCS1 chr3 52704955 52711148 + TAGLN2 chr1 159918107 159925732 - RNASEK chr17 7012417 7014532 + EID2 chr19 39538707 39540161 - C1orf21 chr1 184387029 184629019 + SLC7A5 chr16 87830023 87869507 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC144548.1 chr12 110387463 110445548 - AL035458.2 chr20 34234840 34281173 - LINC01641 chr1 227393554 227431035 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.