exRNAdisease

Entry Detail

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General Information

Database ID: exR0359452 RNA Name: ADRM1 RNA Type: mRNA Chromosome: chr20 Starnd: + Coordinate: Start Site(bp): 62302093 End Site(bp): 62308862 External Links: ENSG00000130706

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand DDIT4 chr10 72273924 72276036 + MIER2 chr19 301444 344815 - TOPBP1 chr3 133598175 133662380 - HLA-B chr6 31269491 31357188 - NPLOC4 chr17 81556887 81648465 - P2RY11 chr19 10111693 10115372 + TAGLN2 chr1 159918107 159925732 - SREBF2 chr22 41833079 41907307 + TUBA1B chr12 49127782 49131397 - DDX49 chr19 18919705 18929189 + SELENOH chr11 57741250 57743554 + U2AF2 chr19 55654146 55674715 + RPS9 chr19 54200809 54249003 + MT-ND3 chrMT 10059 10404 + PLEC chr8 143915147 143976734 - TEX261 chr2 70985942 70994873 - OTUB1 chr11 63985853 64001811 + GNAO1 chr16 56191489 56357444 + GABARAP chr17 7240008 7242449 - VPS28 chr8 144423601 144428563 - ENO1 chr1 8861000 8879190 - TMEM8B chr9 35814451 35865518 + HSP90AB1 chr6 44246166 44253888 + TMEM120B chr12 121712752 121783001 + NDUFV1 chr11 67605653 67612554 + EMG1 chr12 6970913 6997428 + MTREX chr5 55307989 55425579 + MT-CO3 chrMT 9207 9990 + RGMB chr5 98768650 98798643 + ACAP3 chr1 1292390 1309609 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC139530.1 chr17 81701324 81703300 - BX284668.2 chr1 16870945 16883659 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.