exRNAdisease

Entry Detail

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General Information

Database ID: exR0359469 RNA Name: AGAP1 RNA Type: mRNA Chromosome: chr2 Starnd: + Coordinate: Start Site(bp): 235494043 End Site(bp): 236131800 External Links: ENSG00000157985

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand KAT2A chr17 42113111 42121367 - LIN54 chr4 82909973 83012926 - ENAH chr1 225486835 225653142 - OXSR1 chr3 38165089 38255484 + NCOR2 chr12 124324415 124567589 - LMAN2 chr5 177331567 177351668 - NFATC2IP chr16 28950807 28967097 + C14orf132 chr14 96039324 96093889 + HES6 chr2 238238267 238240662 - SELENOW chr19 47778585 47784686 + HDAC3 chr5 141620876 141636849 - CUL3 chr2 224470150 224585397 - RPUSD1 chr16 784974 788397 - SNX10 chr7 26291895 26374329 + CNOT1 chr16 58519951 58629885 - MEIS1 chr2 66433452 66573869 + GIGYF2 chr2 232697299 232860575 + TEX264 chr3 51662693 51704323 + KIF1A chr2 240713761 240821036 - RPS27A chr2 55231903 55235853 + GNAS chr20 58839718 58911192 + TRAIP chr3 49828601 49856574 - GDAP2 chr1 117863485 117929621 - DYNC1LI1 chr3 32525974 32570858 - SLX1A chr16 30193887 30197561 + LRBA chr4 150264435 151015727 - GAPDH chr12 6534512 6538374 + PSMD7 chr16 74296814 74306288 + SIPA1L2 chr1 232397965 232561558 - HMGA2 chr12 65824131 65966295 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC022400.3 chr10 73674295 73730466 - AGAP1-IT1 chr2 235505751 235507566 + AGAP11 chr10 86970741 87010126 + AL136982.1 chr10 86992406 87010203 + NOP14-AS1 chr4 2934882 2961738 + SLX1A-SULT1A3 chr16 30193892 30204310 + TMEM147-AS1 chr19 35540738 35546029 - XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.