exRNAdisease

Entry Detail

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General Information

Database ID: exR0361415 RNA Name: CKB RNA Type: mRNA Chromosome: chr14 Starnd: - Coordinate: Start Site(bp): 103519667 End Site(bp): 103522833 External Links: ENSG00000166165

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AHNAK chr11 62433542 62556235 - AL513165.2 chr9 37512547 37592469 - AC093525.2 chr16 2496032 2520218 + AC068580.4 chr11 1734821 1763954 - AL669918.1 chr6 32813767 32838822 - AC116366.3 chr5 132410832 132646079 + ACADVL chr17 7217125 7225266 + AHCY chr20 34280268 34311802 - AL136295.1 chr14 24189157 24213473 - AHSA1 chr14 77457870 77469472 + AATF chr17 36948954 37056871 + AC069503.2 chr12 121888809 121921470 + ADD1 chr4 2843857 2930076 + ALDH9A1 chr1 165662216 165698863 - AKAP8L chr19 15380050 15419141 - AFF1 chr4 86935002 87141054 + AL121845.3 chr20 63708864 63739103 + ACACA chr17 37084992 37406836 - AGO2 chr8 140520156 140635633 - ALDOA chr16 30064164 30070457 + ACOT7 chr1 6264269 6394391 - AC010132.3 chr7 42909273 42932174 - AC011448.1 chr19 19516227 19536076 + AIF1L chr9 131096476 131123152 + AKR1B1 chr7 134442356 134459284 - AGAP1 chr2 235494043 236131800 + AL360181.3 chr10 133380017 133420271 + ACTB chr7 5527148 5563784 - AC010323.1 chr19 8308283 8321379 - ACTG1 chr17 81509971 81523847 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC010729.1 chr2 5726253 5730355 + AC016876.2 chr17 7581964 7584086 - AC023509.1 chr12 53441741 53467528 + AC026471.1 chr16 31456711 31459736 - AC093827.4 chr4 86924630 86936202 - AC108134.2 chr16 3156736 3157483 - AL049795.2 chr1 32170733 32176568 + AL133367.1 chr14 103525010 103529072 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.