exRNAdisease

Entry Detail

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General Information

Database ID: exR0361534 RNA Name: CNBP RNA Type: mRNA Chromosome: chr3 Starnd: - Coordinate: Start Site(bp): 129169484 End Site(bp): 129183922 External Links: ENSG00000169714

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ABHD17C chr15 80679684 80755621 + ABR chr17 1003518 1229738 - AC023055.1 chr12 55757275 55827546 - AC040162.1 chr16 67929614 67936017 - AC048338.1 chr12 122207779 122266423 - AC104472.3 chr3 155763043 155854442 - AC116366.3 chr5 132410832 132646079 + ACTA2 chr10 88935074 88991339 - ACTB chr7 5527148 5563784 - ACTN4 chr19 38647649 38731589 + ADIPOR1 chr1 202940826 202958572 - ADIPOR2 chr12 1688574 1788674 + ADNP2 chr18 80109262 80147523 + ADO chr10 62804720 62808479 + ADSL chr22 40346500 40390463 + AEN chr15 88621337 88632281 + AFAP1L1 chr5 149271859 149343637 + AFF1 chr4 86935002 87141054 + AGAP4 chr10 45825594 45853875 - AGPAT3 chr21 43865223 43987592 + AICDA chr12 8602170 8612867 - AJUBA chr14 22971177 22982551 - AL022238.4 chr22 40346529 40410054 + AL035078.4 chr11 31812391 32104665 + AL603832.3 chr1 112702614 112711433 - ALDOA chr16 30064164 30070457 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-345-5p chr14 100307876 100307897 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC005062.1 chr7 19918981 20140453 - AC009084.1 chr16 66942712 66963256 + AC009133.5 chr16 29808679 29812227 + AC087190.3 chr16 9104848 9113181 + AC099329.1 chr3 42785087 42852428 - AC104109.4 chr5 134205614 134371044 - AL096870.2 chr14 24209646 24215987 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.