exRNAdisease

Entry Detail

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General Information

Database ID: exR0362108 RNA Name: DDX17 RNA Type: mRNA Chromosome: chr22 Starnd: - Coordinate: Start Site(bp): 38483438 End Site(bp): 38507660 External Links: ENSG00000100201

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AAMP chr2 218264123 218270257 - AAR2 chr20 36236459 36270918 + AATF chr17 36948954 37056871 + ABHD8 chr19 17292131 17310236 - AC005258.1 chr19 2269525 2341172 + AC006064.6 chr12 6556886 6607367 - AC007998.2 chr18 35443871 35497940 - AC015813.2 chr17 57989038 58007246 - AC107871.1 chr15 68184032 68229718 - AC120057.2 chr17 7240427 7244635 - ACIN1 chr14 23058564 23095614 - ACTB chr7 5527148 5563784 - ACTN1 chr14 68874143 68979440 - ACVR2A chr2 147844517 147930826 + ACVR2B chr3 38453890 38493142 + ADAM10 chr15 58588809 58749791 - ADAM19 chr5 157395534 157575775 - ADAR chr1 154582057 154628013 - ADD1 chr4 2843857 2930076 + AEN chr15 88621337 88632281 + AHCY chr20 34280268 34311802 - AKT2 chr19 40230317 40285536 - AL133352.1 chr10 100505628 100529881 - AL136295.5 chr14 24147548 24166452 + AL136454.1 chr1 192716132 192716653 + AL358113.1 chr9 69035747 69255187 + AL928654.3 chr14 105487199 105492267 + ALDH16A1 chr19 49453225 49471050 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-302d-3p chr4 112648006 112648028 - circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC007952.4 chr17 19112000 19112636 - AC007998.3 chr18 35443869 35467088 - AC016876.2 chr17 7581964 7584086 - AC018809.2 chr3 9958717 9962539 + AC067852.1 chr17 42536510 42562062 + AC132217.1 chr11 2129121 2129964 - AC245014.3 chr1 145281116 145281462 + AD000090.1 chr19 35557956 35581954 + AL132780.1 chr14 22929607 22956374 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.