exRNAdisease

Entry Detail

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General Information

Database ID: exR0362565 RNA Name: EEF1G RNA Type: mRNA Chromosome: chr11 Starnd: - Coordinate: Start Site(bp): 62559596 End Site(bp): 62574086 External Links: ENSG00000254772

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AL513165.2 chr9 37512547 37592469 - AC120057.2 chr17 7240427 7244635 - ABCB7 chrX 75051048 75156732 - AHSA1 chr14 77457870 77469472 + AC091167.2 chr15 90249556 90272208 + ALDH4A1 chr1 18871430 18902724 - AHNAK chr11 62433542 62556235 - AC104581.2 chr17 7925931 7930622 - AKT1S1 chr19 49869033 49878459 - AL139353.1 chr14 31334312 31457441 - AC009690.1 chr15 72284727 72375981 - AHCY chr20 34280268 34311802 - AL669918.1 chr6 32813767 32838822 - ACD chr16 67657512 67660815 - ACTN1 chr14 68874143 68979440 - AC008763.3 chr19 7678501 7682854 + ACTB chr7 5527148 5563784 - AC007192.1 chr19 18153158 18178117 + ADNP chr20 50888916 50931437 - ACAD8 chr11 134253495 134265855 + AAR2 chr20 36236459 36270918 + ADH5 chr4 99070978 99088801 - AC012254.2 chr18 47108188 47176345 - AC087289.3 chr17 75898645 75930129 - AC004997.1 chr22 30285238 30299482 - AC091167.6 chr15 90266317 90314499 + ABCF1 chr6 30571393 30597179 + ADSL chr22 40346500 40390463 + AIP chr11 67483026 67491103 + AATF chr17 36948954 37056871 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-1244 chr2 231713368 231713393 + hsa-miR-3648 chr21 8987026 8987046 + hsa-miR-3654 chr7 133034860 133034878 - hsa-miR-6747-3p chr11 62567011 62567031 - circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC004224.2 chr16 3458071 3515564 + AC004687.1 chr17 58330884 58332508 - AC007952.4 chr17 19112000 19112636 - AC008124.1 chr12 45718046 45727775 - AC010327.5 chr19 55216660 55221616 + AC011461.1 chr19 10490339 10491000 - AC012236.1 chr15 31221999 31230838 - AC015917.2 chr17 28405240 28406796 + AC016876.2 chr17 7581964 7584086 - AC020663.1 chr16 4730115 4752565 - AC021078.1 chr5 149494314 149504670 - AC022167.2 chr16 8848105 8860456 + AC091564.7 chr11 6610883 6616594 - AC107884.1 chr11 7418826 7513644 - AC107959.1 chr8 22984596 23019335 - AC113189.2 chr17 7420103 7444081 + AC113189.4 chr17 7439506 7445966 + AC132217.1 chr11 2129121 2129964 - AC139149.1 chr17 81514047 81527776 + AD000090.1 chr19 35557956 35581954 + AL022311.1 chr22 37876148 37895563 + AL035458.2 chr20 34234840 34281173 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.