exRNAdisease

Entry Detail

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General Information

Database ID: exR0362650 RNA Name: EIF3L RNA Type: mRNA Chromosome: chr22 Starnd: + Coordinate: Start Site(bp): 37848868 End Site(bp): 37889407 External Links: ENSG00000100129

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AAMDC chr11 77821109 77918432 + ACLY chr17 41866917 41930542 - AC008763.3 chr19 7678501 7682854 + AHCYL1 chr1 109984765 110023742 + ACBD3 chr1 226144679 226186741 - ADD1 chr4 2843857 2930076 + AASS chr7 122073549 122144255 - AGPS chr2 177392757 177559299 + AC245033.1 chr15 82536788 82573194 - ACTA1 chr1 229431245 229434098 - AC023055.1 chr12 55757275 55827546 - AC007192.1 chr19 18153158 18178117 + ACIN1 chr14 23058564 23095614 - ABCD3 chr1 94418389 94518666 + ADAMTSL4 chr1 150549369 150560937 + AAMP chr2 218264123 218270257 - ADH5 chr4 99070978 99088801 - AL033529.1 chr1 32465057 32600792 + AGPAT5 chr8 6708642 6761503 + ABCF2 chr7 151207837 151227166 - AL513165.2 chr9 37512547 37592469 - ABCA1 chr9 104781006 104928155 - ACTR3B chr7 152759749 152855378 + AL139353.1 chr14 31334312 31457441 - AC010615.4 chr19 21405159 21491266 + ACADVL chr17 7217125 7225266 + AL035078.4 chr11 31812391 32104665 + ABR chr17 1003518 1229738 - AL358113.1 chr9 69035747 69255187 + ACTB chr7 5527148 5563784 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-155-5p chr21 25573983 25574006 + hsa-miR-1248 chr3 186786675 186786701 + hsa-miR-6733-3p chr1 43171652 43171671 - circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC008738.7 chr19 33207129 33207639 + AC012213.4 chr8 103481266 103481619 - AC016876.2 chr17 7581964 7584086 - AC024940.6 chr12 31280422 31280895 - AC079781.5 chr7 97851688 97972985 - AC245014.3 chr1 145281116 145281462 + AD000090.1 chr19 35557956 35581954 + AL022311.1 chr22 37876148 37895563 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.