exRNAdisease

Entry Detail

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General Information

Database ID: exR0362746 RNA Name: ENO1 RNA Type: mRNA Chromosome: chr1 Starnd: - Coordinate: Start Site(bp): 8861000 End Site(bp): 8879190 External Links: ENSG00000074800

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AL049629.2 chr11 33698261 33722467 - ACAD10 chr12 111686056 111757107 + ACSS2 chr20 34872146 34927962 + AC004832.3 chr22 30409255 30428990 + AC048338.1 chr12 122207779 122266423 - AGFG1 chr2 227472152 227561214 + AHSA1 chr14 77457870 77469472 + AC010422.5 chr19 12664828 12669397 - AC010463.1 chr19 17267418 17282966 + AKR1A1 chr1 45550543 45570049 + AC011448.1 chr19 19516227 19536076 + AHNAK chr11 62433542 62556235 - ACTG1 chr17 81509971 81523847 - AL136295.5 chr14 24147548 24166452 + AC091167.2 chr15 90249556 90272208 + ALDH16A1 chr19 49453225 49471050 + ACTA1 chr1 229431245 229434098 - AC010422.3 chr19 12643831 12648397 - AC073283.3 chr2 47065941 47176511 - AL136454.1 chr1 192716132 192716653 + ABRACL chr6 139028745 139043302 + ALDH18A1 chr10 95605941 95656711 - ABCC1 chr16 15949577 16143074 + AC138811.2 chr16 18788063 18801519 - AC018523.2 chr11 14493783 14520344 - AL033529.1 chr1 32465057 32600792 + AC107871.1 chr15 68184032 68229718 - ACIN1 chr14 23058564 23095614 - AHCY chr20 34280268 34311802 - AAGAB chr15 67200667 67255195 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-103a-3p chr5 168560904 168560926 - hsa-miR-423-3p chr17 30117131 30117153 + hsa-miR-4426 chr1 192716333 192716349 + hsa-miR-6728-3p chr1 8866502 8866522 - circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC004687.1 chr17 58330884 58332508 - AC005261.3 chr19 57350848 57352012 - AC005899.4 chr17 32328441 32329395 + AC007952.4 chr17 19112000 19112636 - AC008124.1 chr12 45718046 45727775 - AC010655.2 chr7 128455937 128469197 + AC010655.4 chr7 128455840 128493859 + AC016876.2 chr17 7581964 7584086 - AC021078.1 chr5 149494314 149504670 - AC023509.1 chr12 53441741 53467528 + AC026362.1 chr12 122975320 122982907 + AC026401.3 chr16 15701237 15702118 + AC079781.5 chr7 97851688 97972985 - AC091057.1 chr15 30658717 30772993 + AC091564.7 chr11 6610883 6616594 - AC097478.1 chr4 89743792 89744305 + AC109460.3 chr16 28974804 28990775 + AC124068.2 chr15 89335053 89336161 + AC132217.1 chr11 2129121 2129964 - AC245014.3 chr1 145281116 145281462 + AD000090.1 chr19 35557956 35581954 + AL022311.1 chr22 37876148 37895563 + AL121832.2 chr20 62386303 62386970 - AL132780.1 chr14 22929607 22956374 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.