exRNAdisease

Entry Detail

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General Information

Database ID: exR0363289 RNA Name: FGFR1 RNA Type: mRNA Chromosome: chr8 Starnd: - Coordinate: Start Site(bp): 38400215 End Site(bp): 38468834 External Links: ENSG00000077782

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ABCC4 chr13 95019835 95301475 - ABCF1 chr6 30571393 30597179 + ABHD17A chr19 1876810 1885547 - ABI2 chr2 203328239 203447728 + AC002996.1 chr12 111753890 111791418 + AC005258.1 chr19 2269525 2341172 + AC067968.1 chr19 44025354 44087318 + AC107871.1 chr15 68184032 68229718 - AC139530.2 chr17 81703371 81720539 + ACACA chr17 37084992 37406836 - ACAD10 chr12 111686056 111757107 + ACLY chr17 41866917 41930542 - ACOT7 chr1 6264269 6394391 - ACTB chr7 5527148 5563784 - ACTG1 chr17 81509971 81523847 - AGAP1 chr2 235494043 236131800 + AGPAT5 chr8 6708642 6761503 + AKIRIN1 chr1 38991276 39006059 + AKR1E2 chr10 4786629 4848062 + AL121845.3 chr20 63708864 63739103 + AL589666.1 chr6 85557978 85615234 - ALDH4A1 chr1 18871430 18902724 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-214-3p chr1 172138816 172138837 - hsa-miR-184 chr15 79209840 79209861 + hsa-miR-195-5p chr17 7017667 7017687 - hsa-miR-543 chr14 101032033 101032054 + hsa-miR-1286 chr22 20249145 20249165 - hsa-miR-1294 chr5 154347153 154347174 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC022167.2 chr16 8848105 8860456 + AL022311.1 chr22 37876148 37895563 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.