exRNAdisease

Entry Detail

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General Information

Database ID: exR0363330 RNA Name: FKBP8 RNA Type: mRNA Chromosome: chr19 Starnd: - Coordinate: Start Site(bp): 18531751 End Site(bp): 18544077 External Links: ENSG00000105701

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ABCA5 chr17 69244311 69327244 - ABCC4 chr13 95019835 95301475 - ABR chr17 1003518 1229738 - AC007192.1 chr19 18153158 18178117 + AC008878.3 chr19 7382834 7470241 + AC010132.3 chr7 42909273 42932174 - AC012184.2 chr16 70299194 70372582 + AC024592.3 chr19 5866171 5903787 - AC055811.2 chr17 17202649 17237185 - AC073896.1 chr12 56285916 56316059 - AC138811.2 chr16 18788063 18801519 - ACAT2 chr6 159762045 159779112 + ACTB chr7 5527148 5563784 - ACTG1 chr17 81509971 81523847 - ACTR1A chr10 102461881 102502712 - ADCK5 chr8 144373101 144393242 + ADGRE2 chr19 14732392 14778560 - ADGRL1 chr19 14147743 14206187 - ADO chr10 62804720 62808479 + AEN chr15 88621337 88632281 + AFDN chr6 167826922 167972023 + AGPAT3 chr21 43865223 43987592 + AHCTF1 chr1 246839098 246931967 - AIFM1 chrX 130129362 130165887 - AKAP10 chr17 19904302 19978343 - AKNA chr9 114334156 114394405 - AL365205.1 chr6 41780349 41790141 + AL603832.3 chr1 112702614 112711433 - ALCAM chr3 105366909 105576900 + ALDOA chr16 30064164 30070457 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-3652 chr12 103930425 103930442 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC005899.4 chr17 32328441 32329395 + AC010615.2 chr19 21444241 21463908 - AC026362.1 chr12 122975320 122982907 + AC069281.2 chr7 100572232 100578700 - AC074183.1 chr7 84939349 84940245 - AC099778.1 chr3 47379089 47380999 - AC106864.1 chr4 112693047 112706810 - AC109460.3 chr16 28974804 28990775 + AC113189.2 chr17 7420103 7444081 + AC113189.4 chr17 7439506 7445966 + AC245014.3 chr1 145281116 145281462 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.