exRNAdisease

Entry Detail

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General Information

Database ID: exR0363341 RNA Name: FLNA RNA Type: mRNA Chromosome: chrX Starnd: - Coordinate: Start Site(bp): 154348524 End Site(bp): 154374638 External Links: ENSG00000196924

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AATF chr17 36948954 37056871 + ABCA2 chr9 137007234 137028922 - ABHD17A chr19 1876810 1885547 - AC008403.1 chr19 48465837 48472431 + AC008982.1 chr19 38817471 38840178 - AC027644.4 chr7 66628958 66811189 + AC138969.1 chr16 16317444 16350590 + AC233992.2 chr8 144353228 144355609 - AC245033.1 chr15 82536788 82573194 - ACIN1 chr14 23058564 23095614 - ACTB chr7 5527148 5563784 - ADAMTS1 chr21 26835755 26845409 - ADAMTS19 chr5 129460281 129738683 + ADAMTSL4 chr1 150549369 150560937 + ADCY3 chr2 24819169 24919839 - ADCY6 chr12 48766194 48789037 - ADGRE5 chr19 14380501 14408725 + ADIPOR1 chr1 202940826 202958572 - ADNP2 chr18 80109262 80147523 + AFDN chr6 167826922 167972023 + AFG3L2 chr18 12328944 12377227 - AFMID chr17 78187317 78207701 + AGO2 chr8 140520156 140635633 - AGPAT1 chr6 32168212 32178096 - AGRN chr1 1020120 1056118 + AIP chr11 67483026 67491103 + AK4 chr1 65147549 65232145 + AKT2 chr19 40230317 40285536 - AL807752.6 chr9 137031241 137040436 - ALDH7A1 chr5 126531200 126595362 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-103a-3p chr5 168560904 168560926 - hsa-miR-5100 chr10 42997630 42997651 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC015961.2 chr18 37243776 37247506 + AC026362.1 chr12 122975320 122982907 + AC079781.5 chr7 97851688 97972985 - AD000090.1 chr19 35557956 35581954 + AL021707.2 chr22 38667585 38681847 - AL137127.1 chr1 19072110 19075511 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.