exRNAdisease

Entry Detail

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General Information

Database ID: exR0363628 RNA Name: GDI2 RNA Type: mRNA Chromosome: chr10 Starnd: - Coordinate: Start Site(bp): 5765223 End Site(bp): 5842132 External Links: ENSG00000057608

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ADH5 chr4 99070978 99088801 - ABHD17A chr19 1876810 1885547 - ADIPOR2 chr12 1688574 1788674 + ACAA2 chr18 49782164 49813953 - AC026954.2 chr17 7312661 7319174 - AC010422.3 chr19 12643831 12648397 - AC245033.1 chr15 82536788 82573194 - AC008763.2 chr19 7629796 7643048 + ADCY6 chr12 48766194 48789037 - ADO chr10 62804720 62808479 + ACTB chr7 5527148 5563784 - ADK chr10 74151202 74709963 + AC073283.3 chr2 47065941 47176511 - ACADVL chr17 7217125 7225266 + ALDOA chr16 30064164 30070457 + AD000671.1 chr19 35745678 35754519 + ACADM chr1 75724347 75787575 + ADCY2 chr5 7396138 7830081 + ADAMTS19 chr5 129460281 129738683 + ADAMTS13 chr9 133414358 133459402 + ACTG1 chr17 81509971 81523847 - ACSL3 chr2 222860942 222944639 + AC073508.2 chr17 40627356 40665141 - AFDN chr6 167826922 167972023 + AFG3L2 chr18 12328944 12377227 - ACOT9 chrX 23701055 23766475 - ALDH18A1 chr10 95605941 95656711 - AC000093.1 chr22 19717220 19724772 + ACSS2 chr20 34872146 34927962 + ABHD17B chr9 71862452 71910931 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC009446.1 chr8 71675300 71702786 + AC010542.4 chr16 66549280 66551189 + AC016876.2 chr17 7581964 7584086 - AC124068.2 chr15 89335053 89336161 + AC147067.1 chr4 1574062 1580253 - AC245033.4 chr15 82533175 82540008 - AL021707.2 chr22 38667585 38681847 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.