exRNAdisease

Entry Detail

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General Information

Database ID: exR0364017 RNA Name: GSTP1 RNA Type: mRNA Chromosome: chr11 Starnd: + Coordinate: Start Site(bp): 67583742 End Site(bp): 67586656 External Links: ENSG00000084207

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ADAM17 chr2 9488486 9556732 - ACAD8 chr11 134253495 134265855 + AC008982.1 chr19 38817471 38840178 - ADCY7 chr16 50246137 50318135 + AL035078.4 chr11 31812391 32104665 + AL022238.4 chr22 40346529 40410054 + ACTB chr7 5527148 5563784 - ACSF2 chr17 50426158 50474845 + AC012184.2 chr16 70299194 70372582 + ADRM1 chr20 62302093 62308862 + ADCY3 chr2 24819169 24919839 - AC010323.1 chr19 8308283 8321379 - ACADVL chr17 7217125 7225266 + AC023055.1 chr12 55757275 55827546 - ABCF3 chr3 184186023 184194012 + ALDOA chr16 30064164 30070457 + ACTG1 chr17 81509971 81523847 - ADGRL2 chr1 81306160 81992436 + ABHD12 chr20 25294742 25390835 - ABRAXAS2 chr10 124801819 124836667 + AC004922.1 chr7 99325879 99394653 + ACTR1B chr2 97655939 97664044 - AL132780.3 chr14 22946270 22982258 - ADAR chr1 154582057 154628013 - AC010463.1 chr19 17267418 17282966 + ACOT13 chr6 24667035 24705065 + ACACA chr17 37084992 37406836 - ADSL chr22 40346500 40390463 + AC092073.1 chr19 34396315 34409364 + ALDH1L1 chr3 126103562 126197994 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-23a-3p chr19 13836595 13836615 - circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC009446.1 chr8 71675300 71702786 + AC016876.2 chr17 7581964 7584086 - AC026362.1 chr12 122975320 122982907 + AC139149.1 chr17 81514047 81527776 + AD000090.1 chr19 35557956 35581954 + AL138828.1 chr6 135991936 136225751 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.