exRNAdisease

Entry Detail

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General Information

Database ID: exR0364217 RNA Name: HLA-A RNA Type: mRNA Chromosome: chr6 Starnd: + Coordinate: Start Site(bp): 29941260 End Site(bp): 29945884 External Links: ENSG00000206503

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ACHE chr7 100889994 100896974 - ACTR3 chr2 113890063 113962596 + ABCD1 chrX 153724856 153744755 + AGGF1 chr5 77029251 77065234 + ABHD2 chr15 89087459 89202355 + AC005258.1 chr19 2269525 2341172 + AKR1A1 chr1 45550543 45570049 + ACO2 chr22 41469117 41528989 + ACTB chr7 5527148 5563784 - ACTC1 chr15 34790230 34795549 - ADCY1 chr7 45574140 45723116 + AFG3L2 chr18 12328944 12377227 - AL162417.1 chr9 133098121 133163914 - ALDOA chr16 30064164 30070457 + AFTPH chr2 64524305 64593005 + AL807752.6 chr9 137031241 137040436 - AC092073.1 chr19 34396315 34409364 + AC004922.1 chr7 99325879 99394653 + AGPAT1 chr6 32168212 32178096 - AL022238.4 chr22 40346529 40410054 + AHCY chr20 34280268 34311802 - AC007192.1 chr19 18153158 18178117 + AHCYL1 chr1 109984765 110023742 + AL136295.5 chr14 24147548 24166452 + ACIN1 chr14 23058564 23095614 - AL136454.1 chr1 192716132 192716653 + AC120057.2 chr17 7240427 7244635 - AGO1 chr1 35869808 35930532 + AC027644.4 chr7 66628958 66811189 + AC068547.1 chr2 151802651 151973949 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-4680-5p chr10 110898094 110898116 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC007952.4 chr17 19112000 19112636 - AC008443.1 chr5 181246507 181272167 + AC009686.2 chr8 80032724 80033300 - AC010327.5 chr19 55216660 55221616 + AC016876.2 chr17 7581964 7584086 - AC023509.1 chr12 53441741 53467528 + AC026362.1 chr12 122975320 122982907 + AC084824.5 chr12 32736930 32737660 - AC245884.11 chr19 54308915 54337168 - AL022311.1 chr22 37876148 37895563 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.