exRNAdisease

Entry Detail

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General Information

Database ID: exR0364229 RNA Name: HLA-DRA RNA Type: mRNA Chromosome: chr6 Starnd: + Coordinate: Start Site(bp): 32439878 End Site(bp): 32445046 External Links: ENSG00000204287

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AC104452.1 chr3 49416777 49429314 - AL133352.1 chr10 100505628 100529881 - AC010323.1 chr19 8308283 8321379 - AC012254.2 chr18 47108188 47176345 - AL136295.1 chr14 24189157 24213473 - AC126283.2 chr4 109713916 109801999 - AC010132.3 chr7 42909273 42932174 - AFG3L2 chr18 12328944 12377227 - ABHD10 chr3 111979010 111993368 + AK2 chr1 33007940 33080996 - ACSL4 chrX 109624244 109733403 - ADPRHL2 chr1 36088892 36093932 + AC011005.1 chr7 129126518 129130793 + ACTR1B chr2 97655939 97664044 - AC007192.1 chr19 18153158 18178117 + AC010422.6 chr19 12525720 12580975 - ADRM1 chr20 62302093 62308862 + AC011462.1 chr19 41350853 41425001 + ACTR2 chr2 65227753 65271253 + ABCF1 chr6 30571393 30597179 + ABLIM1 chr10 114431113 114768061 - ABCF2 chr7 151207837 151227166 - AC004223.3 chr17 35011349 35121493 - AC010547.4 chr16 71447600 71489311 - ACADVL chr17 7217125 7225266 + ACTA1 chr1 229431245 229434098 - ABHD17B chr9 71862452 71910931 - AKIRIN2 chr6 87674860 87702233 - ACTB chr7 5527148 5563784 - AFDN chr6 167826922 167972023 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-320a-3p chr8 22244975 22244996 - hsa-miR-155-5p chr21 25573983 25574006 + hsa-miR-155-3p chr21 25574022 25574043 + hsa-miR-3652 chr12 103930425 103930442 + hsa-miR-3654 chr7 133034860 133034878 - circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC005899.4 chr17 32328441 32329395 + AC007952.4 chr17 19112000 19112636 - AC009403.1 chr7 155611231 155645205 - AC009403.2 chr7 155474256 155644406 - AC010969.2 chr2 9936360 9939590 + AC022400.3 chr10 73674295 73730466 - AC023509.1 chr12 53441741 53467528 + AC026362.1 chr12 122975320 122982907 + AC099778.1 chr3 47379089 47380999 - AC245014.3 chr1 145281116 145281462 + AD000090.1 chr19 35557956 35581954 + AL022311.1 chr22 37876148 37895563 + AL096870.2 chr14 24209646 24215987 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.