exRNAdisease

Entry Detail

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General Information

Database ID: exR0364230 RNA Name: HLA-DRB1 RNA Type: mRNA Chromosome: chr6 Starnd: - Coordinate: Start Site(bp): 32578769 End Site(bp): 32589848 External Links: ENSG00000196126

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ABCF1 chr6 30571393 30597179 + ABHD17A chr19 1876810 1885547 - AC004832.3 chr22 30409255 30428990 + AC005258.1 chr19 2269525 2341172 + AC007192.1 chr19 18153158 18178117 + AC010422.3 chr19 12643831 12648397 - AC018523.2 chr11 14493783 14520344 - AC026464.1 chr16 69335276 69351730 - AC026464.3 chr16 69335091 69356306 - AC040162.1 chr16 67929614 67936017 - AC068946.2 chr2 219209772 219222738 - AC092143.1 chr16 89919165 89936092 + ACAT2 chr6 159762045 159779112 + ACOT13 chr6 24667035 24705065 + ACTA1 chr1 229431245 229434098 - ACTB chr7 5527148 5563784 - ACTG1 chr17 81509971 81523847 - ACTR1A chr10 102461881 102502712 - ACTR2 chr2 65227753 65271253 + ADH5 chr4 99070978 99088801 - AHCYL1 chr1 109984765 110023742 + AKAP11 chr13 42272152 42323261 + AKNA chr9 114334156 114394405 - AL034430.1 chr20 10413520 10431922 - AL121594.1 chr14 35122549 35317474 + AL139011.2 chr1 160216800 160285130 - AL603832.3 chr1 112702614 112711433 - AL669918.1 chr6 32813767 32838822 - ALDH4A1 chr1 18871430 18902724 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC007952.4 chr17 19112000 19112636 - AC009403.1 chr7 155611231 155645205 - AC010168.2 chr12 14762504 14767931 - AC011467.3 chr19 22603269 22608501 + AC012368.1 chr2 64143239 64252859 + AC026362.1 chr12 122975320 122982907 + AC079781.5 chr7 97851688 97972985 - AD000090.1 chr19 35557956 35581954 + AL022311.1 chr22 37876148 37895563 + AL031282.2 chr1 1702736 1737688 - AL049795.2 chr1 32170733 32176568 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.