exRNAdisease

Entry Detail

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General Information

Database ID: exR0364376 RNA Name: HSP90AA1 RNA Type: mRNA Chromosome: chr14 Starnd: - Coordinate: Start Site(bp): 102080738 End Site(bp): 102139699 External Links: ENSG00000080824

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AC093525.2 chr16 2496032 2520218 + ADD3 chr10 109996368 110135565 + AL110118.2 chr14 93184973 93218586 + ADCY5 chr3 123282296 123449758 - AL133352.1 chr10 100505628 100529881 - AFDN chr6 167826922 167972023 + ACLY chr17 41866917 41930542 - AL034430.1 chr20 10413520 10431922 - ACO1 chr9 32384603 32454769 + AL121753.1 chr20 35267885 35280043 - ABR chr17 1003518 1229738 - AD000671.1 chr19 35745678 35754519 + AKAP1 chr17 57085092 57121346 + AIF1L chr9 131096476 131123152 + AC015813.2 chr17 57989038 58007246 - AHCY chr20 34280268 34311802 - ACTG1 chr17 81509971 81523847 - AC120057.2 chr17 7240427 7244635 - AKIRIN2 chr6 87674860 87702233 - AL136454.1 chr1 192716132 192716653 + ABCD3 chr1 94418389 94518666 + ACTN1 chr14 68874143 68979440 - ALDH7A1 chr5 126531200 126595362 - AC091167.2 chr15 90249556 90272208 + ABLIM1 chr10 114431113 114768061 - AC023055.1 chr12 55757275 55827546 - AC010422.3 chr19 12643831 12648397 - AL139011.2 chr1 160216800 160285130 - AAMP chr2 218264123 218270257 - AEN chr15 88621337 88632281 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-103a-3p chr5 168560904 168560926 - hsa-miR-146a-5p chr5 160485372 160485393 + hsa-miR-1306-3p chr22 20086112 20086129 + hsa-miR-4709-5p chr14 74480175 74480196 - circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC006511.5 chr12 8014093 8019007 - AC007952.4 chr17 19112000 19112636 - AC024940.6 chr12 31280422 31280895 - AC078883.1 chr2 172480840 172556596 - AC113189.2 chr17 7420103 7444081 + AC113189.4 chr17 7439506 7445966 + AC132217.1 chr11 2129121 2129964 - AC139149.1 chr17 81514047 81527776 + AC145207.5 chr17 81878425 81881106 - AF106564.1 chr8 24912165 24914717 - AL136985.3 chr1 58715609 58771295 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.