exRNAdisease

Entry Detail

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General Information

Database ID: exR0364605 RNA Name: ILF3 RNA Type: mRNA Chromosome: chr19 Starnd: + Coordinate: Start Site(bp): 10654261 End Site(bp): 10692417 External Links: ENSG00000129351

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AC010422.3 chr19 12643831 12648397 - AGO1 chr1 35869808 35930532 + AC093525.2 chr16 2496032 2520218 + AC105052.3 chr7 102637049 102671641 - AC105052.1 chr7 102582523 102642869 - ACY1 chr3 51983340 51989197 + ADH5 chr4 99070978 99088801 - ADARB1 chr21 45073853 45226560 + ACTL6A chr3 179562886 179588407 + AGPAT2 chr9 136673143 136687457 - AC005258.1 chr19 2269525 2341172 + ALDOA chr16 30064164 30070457 + ABCA7 chr19 1039997 1065572 + AASS chr7 122073549 122144255 - ABHD14A-ACY1 chr3 51974706 51989183 + AL035078.4 chr11 31812391 32104665 + ACOT7 chr1 6264269 6394391 - AEN chr15 88621337 88632281 + AKR1A1 chr1 45550543 45570049 + AGAP1 chr2 235494043 236131800 + AL590132.1 chr1 210858125 211134146 - ABCF1 chr6 30571393 30597179 + AC011462.1 chr19 41350853 41425001 + AC027796.3 chr17 3585149 3636249 - ACTG1 chr17 81509971 81523847 - AC124312.1 chr15 24955034 25000276 + ACTB chr7 5527148 5563784 - AL031708.1 chr16 1632259 1686715 + ACBD6 chr1 180269653 180502954 - ABHD14B chr3 51968510 51983409 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-147a chr9 120244985 120245004 - hsa-miR-27b-3p chr9 95085505 95085525 + hsa-miR-513a-5p chrX 147213538 147213555 - circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC010536.1 chr16 87693537 87696147 - AC125807.2 chr12 3041437 3044950 + AC132217.1 chr11 2129121 2129964 - AC139149.1 chr17 81514047 81527776 + AD000090.1 chr19 35557956 35581954 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.