exRNAdisease

Entry Detail

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General Information

Database ID: exR0365266 RNA Name: LCP1 RNA Type: mRNA Chromosome: chr13 Starnd: - Coordinate: Start Site(bp): 46125920 End Site(bp): 46211871 External Links: ENSG00000136167

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ABCD4 chr14 74285269 74303055 - AC004922.1 chr7 99325879 99394653 + AC008982.1 chr19 38817471 38840178 - AC012254.2 chr18 47108188 47176345 - AC023055.1 chr12 55757275 55827546 - ACAP2 chr3 195274745 195443044 - ACBD5 chr10 27195214 27242130 - ACP1 chr2 264140 278283 + ACSS1 chr20 25006230 25058980 - ACTB chr7 5527148 5563784 - ACTBL2 chr5 57480018 57482811 - ACTG1 chr17 81509971 81523847 - ACTR3C chr7 150243916 150323725 - ADAR chr1 154582057 154628013 - ADSL chr22 40346500 40390463 + AFG3L2 chr18 12328944 12377227 - AFTPH chr2 64524305 64593005 + AGPAT4 chr6 161129967 161274061 - AHSA1 chr14 77457870 77469472 + AKR1A1 chr1 45550543 45570049 + AL021546.1 chr12 120438198 120460006 + AL022238.4 chr22 40346529 40410054 + AL109827.1 chr20 35632340 35674544 - AL139300.1 chr14 103562962 103685924 + ALAS1 chr3 52198086 52214327 + ALDOA chr16 30064164 30070457 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-155-5p chr21 25573983 25574006 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC006064.5 chr12 6510275 6510522 + AC026202.2 chr3 5156905 5187329 - AC026202.3 chr3 5187172 5188298 - AC055860.1 chr11 18000542 18022931 - AC079781.5 chr7 97851688 97972985 - AC135048.1 chr16 30948386 30956511 + AC245014.3 chr1 145281116 145281462 + AL022311.1 chr22 37876148 37895563 + AL137058.2 chr13 52600042 52642542 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.